- beauty
- food
- industrial
- pharma
Indigotindisulfonate sodium
CAS 860-22-0 · 40/100 · High conf.
Concern score
40/100Moderate concern based on regulatory listings.
High confidence
Indigotindisulfonate sodium in plain language
On cosmetic ingredient lists it appears as “Acid blue 74”.
Also known as Acid blue 74 · Acid blue 74 aluminum lake · CI 73015 · Indigo carmine · Indigocarmine · C.I. Acid Blue 74
Show all 28 names
Indigotine · AO2 · C.I. 73015 · C.I. 75781 · C.i.food blue 1 · Indigotindisulphonate sodium · 1311 Blue · Aniline Carmine Powder · Bleu covalac w 6504 · Bludigo · Basovit Blue 665E · Blue 2 · Blue No. 2 · CI-(1975)NO.73015 · E-132 · FD & C Blue No. 2 · Gardenia grun P-AC-8 · Holunder P-AC-5 · Indigotine 85% · Ins NO.132 · INS-132 · columbia blue shade
Used in cosmetics as a colourant and a hair dye. CI 73015 is classed chemically as an indigoid colour.
- Colorant
- Hair dyeing
- Colour
- Colourant
- Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
What the listings say
Permitted, with conditions — Indigotindisulfonate sodium appears on published "allowed" regulatory lists rather than on a restriction list.
Disodium 5,5'-(2-(1,3-dihydro-3-oxo-2H-indazol-2-ylidene)-1,2-dihydro-3H-indol-3-one)disulphonate is listed in Annex IV of the EU Cosmetics Regulation (EC) 1223/2009 (colorants allowed in cosmetic products).
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
No restrictions found. Indigotindisulfonate sodium appears in these published regulatory listings.
- In marketed US drugs
- EU Annex IV — permitted colorant
- EU permitted colorant
- Inactive ingredient in US drugs
- Found in consumer products
- Beauty
- Pharma
- Food
- Industrial
EUECallowed_listedAnnex IV of EU Cosmetics Regulation (EC) 1223/2009: colorants allowed in cosmetic products. Conditions of use and warnings: Purity criteria as set out in Commission Directive 95/45/EC (E 132)
- Annex IV of EU Cosmetics Regulation (EC) 1223/2009: colorants allowed in cosmetic products. Conditions of use and warnings: Purity criteria as set out in Commission Directive 95/45/EC (E 132)Source →
GLOBALJECFA0-5 mg/kg bwJECFA evaluation lists ADI 0-5 mg/kg bw. Functional class: colour.
- JECFA evaluation lists ADI 0-5 mg/kg bw. Functional class: colour.Source →
GLOBALJECFAEvaluatedJECFA evaluation record.
- JECFA evaluation record.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 25 composition records across product categories including Personal care, Laboratory supplies, Industrial products. EPA CPDat classifies this chemical for functional uses including Dye.
- EPA CPDat observed this chemical in 25 composition records across product categories including Personal care, Laboratory supplies, Industrial products. EPA CPDat classifies this chemical for functional uses including Dye.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
- FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
Expert safety opinions
Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
Scientific Opinion on the safety and efficacy of indigo carmine (E 132) for cats and dogs and ornamental fish (EFSA FEEDAP)
2015 · EU EFSA listing · Read the source →
Scientific Opinion on the re-evaluation of Indigo Carmine (E 132) as a food additive (EFSA ANS)
2014 · EU EFSA listing · Read the source →
JECFA
Joint FAO/WHO Expert Committee on Food Additives
JECFA evaluation lists ADI 0-5 mg/kg bw. Functional class: colour.
Year not recorded · GLOBAL JECFA listing · Read the source →
JECFA evaluation record.
Year not recorded · GLOBAL JECFA listing · Read the source →
Evidence & sources
No graded research studies for Indigotindisulfonate sodium yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2020-08-14
- Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
- Open →
EPA Chemical and Products Database
exposure · updated January 7, 2008
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
- Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
WHO JECFA Database
regulatory · updated 2026-10-04
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Reference links (2)
codexalimentarius.net
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
Where it has been recorded
How often EPA CPDat has listed Indigotindisulfonate sodium in a product composition. These are source records, not Greenveil catalog products.
Source records
25
Named organisations
5
Personal careLaboratory suppliesIndustrial productsFood and drug
Typical roles
ColorantHair dyeingColourColourant
Found in these products
Their ingredient lists include Indigotindisulfonate sodium; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
