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Rauwolfia serpentia L., alkaloids and their salts

CAS 90106-13-1 · 100/100 · High conf.

Concern score

100/100Critical concern based on regulatory listings.
High confidence

Rauwolfia serpentia L., alkaloids and their salts in plain language

What it is

On cosmetic ingredient lists it appears as “Rauvolfia serpentina root extract”.

Also known as Rauvolfia serpentina root extract · Rauwolfia serpentina extract · Rauwolfia extract · Rauwolfia serpentina

What it does

Used in cosmetics as a skin-conditioning agent and an astringent. Rauvolfia Serpentina Root Extract is the extract of the roots of Rauvolfia serpentine, Apocynaceae.

  • Skin conditioning
  • Astringent
  • Conditioner
Is it a concern?
Critical concern: no hazard classifications on record. It is banned in EU cosmetics.

Why it's flagged

Rauwolfia serpentia L., alkaloids and their salts is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — banned

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • EU Annex II — prohibited
  • EU prohibited in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products.

    banned
    View source →
  • EUCosIngActive3 entries
    • Rauvolfia Serpentina Root Extract is the extract of the roots of Rauvolfia serpentine, Apocynaceae.Source →
    • Rauwolfia Serpentina Extract is an extract of the roots of the Rauwolfia, Rauwolfia serpentina (L.), Apocynaceae Restriction: II/15Source →
    • Cosmetics Regulation annex II / ref 15.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Astringent, Softener and conditioner.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Astringent, Softener and conditioner.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 20 active drug products and 21 total products.
    • FDA NDC lists this ingredient in 20 active drug products and 21 total products.Source →

Expert safety opinions

No expert opinion on file for Rauwolfia serpentia L., alkaloids and their salts. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Rauwolfia serpentia L., alkaloids and their salts yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2010-10-17

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2020-02-13

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2029-02-21

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often FDA National Drug Code directory has listed Rauwolfia serpentia L., alkaloids and their salts in a product composition. These are source records, not Greenveil catalog products.

Source records

21

Typical roles

Skin conditioningAstringentConditioner
See products using Rauwolfia serpentia L., alkaloids and their salts →