Isatin

Isatin in plain language

What it is

Also known as 1H-Indole-2,3-Dione · O-aminobenzoylformic anhydride · Pseudoisatin · 2,3-Dihydro-1H-indole-2,3-dione · 2,3-Diketoindoline · 2,3-Dioxo-2,3-dihydroindole

Show all 16 names

2,3-Dioxoindoline · 2,3-Indolindione · 2,3-Indolinedione · Indole-2,3-dione · Indoline-2,3-dione · Isatic acid lactam · Isatine · Isatinic acid anhydride · Isotin · Tribulin

What it does

Used in cosmetics as a hair dye.

• Hair dyeing
• Colourant

Is it a concern?

High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

1H-Indole-2,3-Dione is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

• EU Annex III — restricted
• EU restricted in cosmetics

• EU·EC

  Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: Hair dye substance in non-oxidative hair dye products Maximum concentration: 1.6% Conditions of use and warnings: Hair colorants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever experienced any reaction after colouring your hair, —…

  restricted
  View source →

• EU·CosIng·Active2 entries

  • Cosmetics Regulation annex III / ref 210.Source →
  • Restriction: Annex III/210Source →
• US·EPA·commercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.

  • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.Source →
• US·FDA·listed in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.

  • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Isatin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

• SCCS

  EU Scientific Committee on Consumer Safety

  No SCCS opinion on file.

• CIR

  Cosmetic Ingredient Review (US expert panel)

  No CIR safety assessment on file.