# Safrole

URL: https://app.greenveil.ai/ingredients/ingredient_cas_94_59_7
Categories: beauty, cleaning, industrial
Functions: Fragrance, Flavouring
Identifier: 94-59-7

> Safrole: Used in consumer products as a fragrance ingredient and a flavouring. Greenveil chemical-concern score: 100/100 — Critical concern driven by cmr.. Compiled from 7 published data sources.

## Safety assessment

- Chemical concern score: 100/100 — Critical concern driven by cmr.
- Confidence in this assessment: High
- Is it a concern? Critical concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is banned in EU cosmetics.
- Rationale: Safrole, except for normal content in the natural essences used and provided that the concentration does not exceed: 100 ppm in the finished cosmetic product, 50 ppm in products for dental and oral hygiene, and provided that Safrole is not present in toothpastes intended specifically for children is prohibited in cosmetic products under Annex II of the EU Cosmetics Regulation (EC) 1223/2009.

## Regulatory status

- EU: Active — Cosmetics Regulation annex II / ref 360.
- EU: banned — Annex II of EU Cosmetics Regulation (EC) 1223/2009: substances prohibited in cosmetic products. CMR: Carcinogenic Cat. 1B(),Mutagenic Cat. 2()
- US: commercial use observed — EPA CPDat observed this chemical in 8 composition records across product categories including Laboratory supplies, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/28699
- EU CosIng Cosmetics Regulation Annexes (updated 2016-11-24): https://ec.europa.eu/growth/tools-databases/cosing/reference/annexes/list/II
- EPA Chemical and Products Database (updated March 8, 2019): http://siri.org/msds/f2/bbp/bbpcg.html
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:RSB34337V9
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/5144

_Assessed by Greenveil._