beauty
food
industrial

Isoeugenol

CAS 97-54-1 · 70/100 · High conf.

Also registered as 2 other CAS numbers

5912-86-7 · 5932-68-3

Concern score

70/100High concern based on regulatory listings.

High confidence

Isoeugenol in plain language

What it is: Also known as Isoeugenol trans-form · (E)-Isoeugenol · Isoeugenol, (e)- · Isoeugenol, e- · (E)-2-Methoxy-4-(1-propenyl)phenol · (E)-4-PROPENYLGUAIACOL
Show all 28 names
1-(3-Methoxy-4-hydroxyphenyl)-1-propene · 1-Hydroxy-2-methoxy-4-propen-1-ylbenzene · 2-METHOXY-4-(1-PROPENYL)PHENOL · 2-Methoxy-4(E)-1-propenylphenol · 2-Methoxy-4-propenylphenol · 2-methoxy-4-(prop-1-en-1-yl)phenol · 3-Methoxy-4-hydroxy-1-propen-1-ylbenzene · 3-Methoxy-4-hydroxypropenylbenzene · 4-Hydroxy-3-methoxy-1-propen-1-ylbenzene · 4-Hydroxy-3-methoxy-1-propenylbenzene · 4-Hydroxy-3-methoxypropenylbenzene · 4-Propenylguaiacol · E-isoeugenol · Isoeugenol, trans- · NCI-C60979 · Phenol, 2-methoxy-4-(1-propenyl)- · Phenol, 2-methoxy-4-(1-propenyl)-, (E)- · Phenol, 2-methoxy-4-(1E)-1-propenyl- · Phenol, 2-methoxy-4-propenyl- · Phenol, 2-methoxy-4-propenyl-, (E)- · trans-Isoeugenol · trans-p-Propenylquaiacol
What it does: Used in cosmetics as a flavouring and a fragrance ingredient.
Flavouring
Perfuming
Flavouring agent
Fragrance
Is it a concern?: High concern: no hazard classifications on record. It is restricted in EU cosmetics.

Why it's flagged

Phenol, 2-methoxy-4-(1-propenyl); (E)-2-methoxy-4-(prop-1-enyl)phenol;(trans-Isoeugenol); (Z)-2-methoxy-4-(prop-1-enyl)phenol;(cis-Isoeugenol) is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

EU Annex III — restricted
EU restricted in cosmetics

Recorded in these product areas

Found in consumer products
Industrial

EUEC
Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Oral products (b) Other products Maximum concentration: b) 0,02 % Other conditions: (a) (b) The presence of the substance shall be indicated in the list of ingredients referred to in Article 19(1), point (g), when its concentration exceeds: — 0,001 % in leave-on products — 0,01 % in rinse-off products.
restricted
View source →

EUCosIngActive2 entries
- Cosmetics Regulation annex III / ref 73.Source →
- Restriction: III/73Source →
EUEFSAEFSA opinion2 entries
- Scientific Opinion on the safety and efficacy of propenylhydroxybenzenes (chemical group 17) when used as flavourings for all animal species (EFSA FEEDAP)Source →
- Scientific Opinion on Flavouring Group Evaluation 81 (FGE.81): Consideration of hydroxypropenylbenzenes evaluated by JECFA (61st meeting) structurally related to 2-methoxy-4-(prop-1-enyl)phenyl 3-methylbutyrate from chemical group 17 evaluated by EFSA in FGE.30. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) (EFSA CEF)Source →
GLOBALJECFANo safety concern at current levels of intake when used as a flavouring agentJECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
- JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance.
- EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Scientific Opinion on the safety and efficacy of propenylhydroxybenzenes (chemical group 17) when used as flavourings for all animal species (EFSA FEEDAP)
  2012 · EU EFSA listing · Read the source →
- Scientific Opinion on Flavouring Group Evaluation 81 (FGE.81): Consideration of hydroxypropenylbenzenes evaluated by JECFA (61st meeting) structurally related to 2-methoxy-4-(prop-1-enyl)phenyl 3-methylbutyrate from chemical group 17 evaluated by EFSA in FGE.30. EFSA Panel on Food Contact Materials, Enzymes, Flavourings and Processing Aids (CEF) (EFSA CEF)
  2010 · EU EFSA listing · Read the source →
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Isoeugenol yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EU CosIng Cosmetics Regulation Annexes
regulatory · updated 2023-09-11
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated 2020-03-19
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Catalog

Found in these products

Their ingredient lists include Isoeugenol; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 190 →Find products without it →