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2-HYDROXYETHYL picramic acid

CAS 99610-72-7 · 70/100 · High conf.

2-HYDROXYETHYL picramic acid chemical structure

Concern score

70/100High concern driven by cmr.
High confidence

2-HYDROXYETHYL picramic acid in plain language

What it is

Also known as 1-Hydroxy-2-beta-hydroxyethylamino-4,6-dinitrobenzene · 2-(2-hydroxyethylamino)-4,6-dinitrophenol · 2-(2-hydroxy-3,5-dinitroanilino)ethanol · 2-hydroxyethyl picramicacid · 4,6-DINITRO-2-(2-HYDROXYETHYL)AMINOPHENOL · AKOS015999886

Show all 10 names

Ec 412-520-9 · Oabrbvcujijmob-uhfffaoysa-n · Q27282517 · UNII-KZ27KOJ0GZ

What it does

Used in cosmetics as a hair dye.

  • Hair dyeing
  • Colourant
Is it a concern?
High concern: classified for carcinogenic, mutagenic or reproductive toxicity (CMR). It is restricted in EU cosmetics.

Why it's flagged

  • Cmr

1-Hydroxy-2-beta-hydroxyethylamino-4,6-dinitrobenzene is restricted in cosmetic products under Annex III of the EU Cosmetics Regulation (EC) 1223/2009.

RestrictedEU EC — restricted

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • EU Annex III — restricted
  • EU restricted in cosmetics

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEC

    Annex III of EU Cosmetics Regulation (EC) 1223/2009: substances which cosmetic products must not contain except subject to the restrictions laid down. Product types: (a) Hair dye substance in oxidative hair day products (b) Hair dye substance in non-oxidative hair day products Maximum concentration: (b) 2.0% Other conditions: (a) After mixing under oxidative conditions the maximum concentration applied to hair must not exceed 1,5% For (a) and (b): - Do not use with nitrosating agents - Maximum nitrosamine content: 50 microgram/kg - Kep in nitrite-free containers Conditions of use and warnings: (a) To be printed on the label: The mixing ratio. “ Hair colourants can cause severe allergic reactions. Read and follow instructions. This product is not intended for use on persons under the age of 16. Temporary ‘black henna’ tattoos may increase your risk of allergy. Do not colour your hair if: — you have a rash on your face or sensitive, irritated and damaged scalp, — you have ever… CMR: Reprotoxic Cat. 2()

    restricted
    View source →
  • EUCosIngActive2 entries
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Dye.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for 2-HYDROXYETHYL picramic acid. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for 2-HYDROXYETHYL picramic acid yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EU CosIng Cosmetics Regulation Annexes

    regulatory · updated 2014-06-05

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2020-02-13

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.