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C18-Ceramide

CAS 136846-30-5

Also registered as 3 other CAS numbers

121461-98-1 · 1195526-02-3 · 2304-81-6

C18-Ceramide chemical structure

Concern score

Not assessed — no hazard data yet.

C18-Ceramide in plain language

What it is

On cosmetic ingredient lists it appears as “Ceramide ns”.

Also known as Ceramide ns · N-stearoyl-d-erythro-sphingosine · C18 Ceramide (d18:1/18:0) · C18 Cer · C36H71NO3 · Cer(d18:1/18:0)

Show all 15 names

Ceramide (d18:1/18:0) · N-((2S,3R,E)-1,3-dihydroxyoctadec-4-en-2-yl)stearamide · N-((E,2s,3r)-1,3-Dihydroxyoctadec-4-En-2-Yl)stearamide · N-(octadecanoyl)-ceramide · N-(octadecanoyl)-sphing-4-enine · N-(stearoyl)-ceramide · N-Stearoyl-D-sphingosine · N-Stearoylsphingosine · N-octadecanoylsphingosine

What it does

Used in cosmetics as a skin-conditioning agent and a hair conditioner.

  • Skin conditioning
  • Hair conditioning
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

What we know about this ingredient

EPA DSSTox provides the canonical identifier, structure, and synonym profile for this chemical.

Regulation

No restrictions found. C18-Ceramide appears in these published regulatory listings.

  • EUCosIngActiveCeramide NS, formerly known under the INCI Name Ceramide 2, is the N-acylated sphingolipid consisting of sphingosine having the D-erythro structure linked to a normal saturated or unsaturated fatty acid. As opposed to the broader definition for Ceramide 2 which includes sphingolipids consisting of either sphingosine or dihydrosphingosine (sphinganine), Ceramide NS is limited to sphingosine-based ceramides.
    • Ceramide NS, formerly known under the INCI Name Ceramide 2, is the N-acylated sphingolipid consisting of sphingosine having the D-erythro structure linked to a normal saturated or unsaturated fatty acid. As opposed to the broader definition for Ceramide 2 which includes sphingolipids consisting of either sphingosine or dihydrosphingosine (sphinganine), Ceramide NS is limited to sphingosine-based ceramides.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for C18-Ceramide. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for C18-Ceramide yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Catalog

Found in these products

Cosmetic and personal-care products that list C18-Ceramide are shown first. Their ingredient lists include C18-Ceramide; each product's own rating depends on its whole formula, so it is shown on the product page, not here.