Is POLYSORBATE 80 Safe? — Ingredient Safety Profile · Greenveil
Ingredients POLYSORBATE 80 beauty / cleaning / food / industrial / pharma
POLYSORBATE 80 EPA CPDat observed this chemical in 1566 composition records across product categories including Food and drug, Pesticides, Raw materials.
Research docs 0 Claims 0 Sources 88 Function anti-fogging agents • Anti-static agent Identifier DTXSID0021175 5
Concern score
5/100 Low concern based on regulatory listings.
How we scored this The concern value reflects this ingredient's chemical identity — its hazard profile from the published classifications and regulatory status below — not the safety of a product it appears in. A score near 40 is the baseline for ingredients with no specific signal (water scores 40 by design), so a mid-range value is not a safety verdict.
Concern score 5/100 (low) · high confidence.
Where it appears Prevalence of POLYSORBATE 80 in our catalog (epa_cpdat).
Food and drug Pesticides Raw materials Cleaning and safety Industrial products Personal care
Typical roles
anti-fogging agents Anti-static agent Cleaning agent Dispersing agent Emulsifier
Catalog
Found in these products 26 products Suitability Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Fragrance avoidance
Not a strong fit for fragrance avoidance because it carries Fragrance.
Linked research Primary documents currently linked to this ingredient record.
No linked research documents are attached to this ingredient yet.
Extracted claims Structured claim signals pulled from linked ingredient research.
No extracted claims are attached to this ingredient yet.
Regulatory status Published jurisdiction-level classifications and regulatory designations for this ingredient.
EPA CPDat observed this chemical in 1566 composition records across product categories including Food and drug, Pesticides, Raw materials. EPA CPDat classifies this chemical for functional uses including Emulsifier, Fragrance, Surfactant (surface active agent).
inactive ingredient database Route: AURICULAR (OTIC); Dosage form: DROPS; Potency: 0.02 %w/w
inactive ingredient database Flavouring and nutrient
Fragrance
Lubricating agent
La Roche-Posay LR
Effaclar duo+
La Roche-Posay
Critical
The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.
Evidence read The published evidence profile currently shaping this ingredient record.
No evidence profiles are attached to this ingredient yet.
Route: AURICULAR (OTIC); Dosage form: SOLUTION; Potency: 0.2 %w/w
inactive ingredient database Route: AURICULAR (OTIC); Dosage form: SOLUTION/ DROPS; Maximum daily exposure: 13 mg
inactive ingredient database Route: AURICULAR (OTIC); Dosage form: SUSPENSION; Potency: 1 %w/v
inactive ingredient database Route: INTRA-ARTICULAR; Dosage form: INJECTION; Maximum daily exposure: 4 mg
inactive ingredient database Route: INTRA-ARTICULAR; Dosage form: INJECTION, POWDER, FOR SUSPENSION; Maximum daily exposure: 5 mg
inactive ingredient database Route: INTRA-ARTICULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 4 mg
inactive ingredient database Route: INTRALESIONAL; Dosage form: INJECTION; Maximum daily exposure: 4 mg
inactive ingredient database Route: INTRALESIONAL; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 4 mg
inactive ingredient database Route: INTRAMUSCULAR; Dosage form: INJECTION; Potency: 4 %w/v
inactive ingredient database Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, FOR SUSPENSION; Maximum daily exposure: 4 mg
inactive ingredient database Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 1 mg
inactive ingredient database Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Potency: 5 %w/v
inactive ingredient database Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 4 mg
inactive ingredient database Route: INTRASYNOVIAL; Dosage form: INJECTION; Potency: 0.2 %w/v
inactive ingredient database Route: INTRASYNOVIAL; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 4 mg
inactive ingredient database Route: INTRAVENOUS; Dosage form: CONCENTRATE; Maximum daily exposure: 4680 mg
inactive ingredient database Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 4680 mg
inactive ingredient database Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: 53 mg
inactive ingredient database Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Maximum daily exposure: 900 mg
inactive ingredient database Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 1170 mg
inactive ingredient database Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION, CONCENTRATE; Maximum daily exposure: 4739 mg
inactive ingredient database Route: INTRAVENOUS; Dosage form: INJECTION, SUSPENSION; Potency: 0.5 %w/v
inactive ingredient database Route: INTRAVENOUS; Dosage form: LIQUID; Maximum daily exposure: 720 mg
inactive ingredient database Route: INTRAVENOUS; Dosage form: SOLUTION; Maximum daily exposure: 900 mg
inactive ingredient database Route: INTRAVITREAL; Dosage form: INJECTION, SUSPENSION; Potency: 0.02 %w/v
inactive ingredient database Route: NASAL; Dosage form: SPRAY; Potency: 0.01 mg
inactive ingredient database Route: NASAL; Dosage form: SPRAY, METERED; Potency: 0.1 mg/1ml
inactive ingredient database Route: OPHTHALMIC; Dosage form: DROPS; Potency: 0.05 %w/w
inactive ingredient database Route: OPHTHALMIC; Dosage form: EMULSION; Maximum daily exposure: 26 mg
inactive ingredient database Route: OPHTHALMIC; Dosage form: SOLUTION; Maximum daily exposure: 8 mg
inactive ingredient database Route: OPHTHALMIC; Dosage form: SOLUTION, GEL FORMING, EXTENDED RELEASE; Potency: 0.05 %w/w
inactive ingredient database Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Potency: 0.25 %w/v
inactive ingredient database Route: OPHTHALMIC; Dosage form: SUSPENSION; Maximum daily exposure: 1 mg
inactive ingredient database Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Maximum daily exposure: 1 mg
inactive ingredient database Route: ORAL; Dosage form: CAPSULE; Potency: 418.37 mg
inactive ingredient database Route: ORAL; Dosage form: CAPSULE, COATED; Potency: 0.04 mg
inactive ingredient database Route: ORAL; Dosage form: CAPSULE, COATED PELLETS; Potency: 2 mg
inactive ingredient database Route: ORAL; Dosage form: CAPSULE, DELAYED RELEASE; Maximum daily exposure: 23 mg
inactive ingredient database Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Maximum daily exposure: 10 mg
inactive ingredient database Route: ORAL; Dosage form: CAPSULE, LIQUID FILLED; Maximum daily exposure: 24 mg
inactive ingredient database Route: ORAL; Dosage form: CONCENTRATE; Potency: 1 mg/1ml
inactive ingredient database Route: ORAL; Dosage form: ELIXIR; Potency: 2.5 mg/15ml
inactive ingredient database Route: ORAL; Dosage form: GRANULE, FOR SUSPENSION; Maximum daily exposure: 240 mg
inactive ingredient database Route: ORAL; Dosage form: PASTE; Maximum daily exposure: 28 mg
inactive ingredient database Route: ORAL; Dosage form: POWDER; Potency: 66 mg
inactive ingredient database Route: ORAL; Dosage form: POWDER, FOR SUSPENSION; Maximum daily exposure: 150 mg
inactive ingredient database Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 907 mg
inactive ingredient database Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 206 mg
inactive ingredient database Route: ORAL; Dosage form: SUSPENSION, EXTENDED RELEASE; Maximum daily exposure: 40 mg
inactive ingredient database Route: ORAL; Dosage form: SUSPENSION/ DROPS; Maximum daily exposure: 23 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 233 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET, CHEWABLE; Maximum daily exposure: 84 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET, COATED; Maximum daily exposure: 18 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET, DELAYED RELEASE; Maximum daily exposure: 4 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Maximum daily exposure: 10 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET, FILM COATED; Potency: 24 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET, FILM COATED, EXTENDED RELEASE; Potency: 8 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET, ORALLY DISINTEGRATING; Maximum daily exposure: 1 mg
inactive ingredient database Route: ORAL; Dosage form: TABLET, ORALLY DISINTEGRATING, DELAYED RELEASE; Maximum daily exposure: 34 mg
inactive ingredient database Route: RECTAL; Dosage form: ENEMA; Potency: 0.01 %w/v
inactive ingredient database Route: RECTAL; Dosage form: SOLUTION; Maximum daily exposure: 315 mg
inactive ingredient database Route: RECTAL; Dosage form: SUPPOSITORY; Potency: 72.15 mg
inactive ingredient database Route: RESPIRATORY (INHALATION); Dosage form: SUSPENSION; Maximum daily exposure: 1 mg
inactive ingredient database Route: SOFT TISSUE; Dosage form: INJECTION; Maximum daily exposure: 4 mg
inactive ingredient database Route: SOFT TISSUE; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 4 mg
inactive ingredient database Route: SUBCUTANEOUS; Dosage form: INJECTION, SUSPENSION; Potency: 0.3 %w/v
inactive ingredient database Route: SUBCUTANEOUS; Dosage form: SUSPENSION; Potency: 0.3 %w/v
inactive ingredient database Route: SUBLINGUAL; Dosage form: TABLET; Potency: 0.08 mg
inactive ingredient database Route: TOPICAL; Dosage form: AEROSOL, FOAM; Potency: 0.98 %w/w
inactive ingredient database Route: TOPICAL; Dosage form: CREAM; Maximum daily exposure: 20 mg
inactive ingredient database Route: TOPICAL; Dosage form: EMULSION; Potency: 2.5 %w/w
inactive ingredient database Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 12 mg
inactive ingredient database Route: TOPICAL; Dosage form: LOTION; Potency: 15 %w/w
inactive ingredient database Route: TOPICAL; Dosage form: OINTMENT; Potency: 0.1 %w/w
inactive ingredient database Route: TOPICAL; Dosage form: SYSTEM; Maximum daily exposure: 28 mg
inactive ingredient database Route: VAGINAL; Dosage form: AEROSOL, FOAM; Potency: 3 %w/w
inactive ingredient database Route: VAGINAL; Dosage form: CREAM; Potency: 0.4 %w/w
inactive ingredient database Route: VAGINAL; Dosage form: SUPPOSITORY; Potency: 28 mg
FDA NDC lists this ingredient in 14 active drug products and 14 total products.
listed in openFDA substance openFDA substance registry classifies this ingredient as polymer.
