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Squalene

CAS 11051-27-7 · 0/100 · High conf.

Also registered as 3 other CAS numbers

94016-35-0 · 111-02-4 · 7683-64-9

Squalene chemical structure

Concern score

0/100Low concern — well-established and permitted without restriction (CIR safe as used; EU CosIng).
High confidence

Squalene in plain language

What it is

Also known as (E)-Squalene · Squalene oil · (E,E,E,E)-Squalene · 2,6,10,15,19,23-Hexamethyl-2,6,10,14,18,22-tetracosahexaene · 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaen · 2,6,10,15,19,23-Hexamethyltetracosa-2,6,10,14,18,22-hexaene

Show all 16 names

All-trans-Squalene · Nikko Squalane EX · Spinacen · Spinacene · Super Squalene · Supraene · squalen · trans-Squalene · MF59 component squalene · Montanide isa 720 component squalene

What it does

Used in cosmetics as an emollient, a solvent and a hair conditioner. Squalene is an unsaturated branched chain isoprenoid hydrocarbon found in fish and plant oils.

  • Emollient
  • Solvent
  • Hair conditioning
Is it a concern?
Low concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 2 composition records across product categories including Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Squalene appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • EUCosIngActiveSqualene is an unsaturated branched chain isoprenoid hydrocarbon found in fish and plant oils. It conforms to the formula: Restriction: Please consider whether entry 419 of Annex II to the Cosmetics Regulation 1223/2009 is applicable. According to entry 419, category 1 material and Category 2 material as defined in Articles 4 and 5 respectively of Regulation (EC) No 1774/2002, and ingredients derived therefrom are prohibited in cosmetics products. Regulation (EC) No 1774/2002 has been repealed and replaced by Regulation No. 1069/2009. For Category 1 and 2 materials in Regulation No. 1069/2009, please see Article 8 and 9, respectively.
    • Squalene is an unsaturated branched chain isoprenoid hydrocarbon found in fish and plant oils. It conforms to the formula: Restriction: Please consider whether entry 419 of Annex II to the Cosmetics Regulation 1223/2009 is applicable. According to entry 419, category 1 material and Category 2 material as defined in Articles 4 and 5 respectively of Regulation (EC) No 1774/2002, and ingredients derived therefrom are prohibited in cosmetics products. Regulation (EC) No 1774/2002 has been repealed and replaced by Regulation No. 1069/2009. For Category 1 and 2 materials in Regulation No. 1069/2009, please see Article 8 and 9, respectively.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 2 composition records across product categories including Personal care.
    • EPA CPDat observed this chemical in 2 composition records across product categories including Personal care.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Squalene. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Squalene yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2019-05-15

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

en.wikipedia.org

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Squalene in a product composition. These are source records, not Greenveil catalog products.

Source records

2

Named organisations

1

Personal care

Typical roles

EmollientSolventHair conditioning
See products using Squalene →

Catalog

Found in these products

Their ingredient lists include Squalene; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 95 →Find products without it →