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Gluconolactone

CAS 135820-79-0 · 40/100 · High conf.

Also registered as 9 other CAS numbers

1335-57-5 · 4253-68-3 · 71033-49-3 · 302547-96-2 · 1020398-69-9 · 1025765-61-0 · 1245945-89-4 · 1542210-74-1 · 90-80-2

Gluconolactone chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Gluconolactone in plain language

What it is

Also known as Glucono delta-lactone · Glucono-delta-lactone · Gdl · delta-Gluconolactone · (3R,4S,5S,6R)-3,4,5-Trihydroxy-6-(hydroxymethyl)oxan-2-one · .delta.-d-gluconolactone

Show all 32 names

D-(+)-Glucono-δ-lactone · D-gluconic acid .delta.-lactone · D-GLUCONO-1,5-LACTONE · Fujiglucon · Glucono .delta. lactone · Lysactone · Riken lactone · 1,5-D-Gluconolactone · 1,5-Gluconolactone · D-(+)-glucono-.delta.-lactone · D-(+)-Gluconic acid δ-lactone · D-Gluconic acid 1,5-lactone · D-Gluconic acid lactone · D-Gluconic acid, δ-lactone · D-Glucono-1,5-lacton · D-glucono-1,5-lactona · Deltagluconolactone · E-575 · Gluconic acid lactone · Gluconic delta-lactone · Gluconic lactone · Ins NO.575 · INS-575 · glucono delta lactone · gluconodeltalactone · Renacidin component gluconolactone

What it does

Used in cosmetics as a skin-conditioning agent and a chelating agent.

  • Skin conditioning
  • Chelating
  • Acid, acidity regulator, raising agent, sequestrant
  • Antioxidant
  • Preservative
  • Humectant
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 1370 composition records across product categories including Laboratory supplies, Personal care, Cleaning products and household care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Gluconolactone appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Industrial
  • USFDAinactive ingredient database6 entries — 4 administration routes
    • Route: ORAL; Dosage form: ELIXIR; Potency: NASource →
    • Route: TOPICAL; Dosage form: CLOTH; Potency: NASource →
    • Route: TOPICAL; Dosage form: SOLUTION; Potency: 0.3 %w/wSource →
    • Route: TOPICAL; Dosage form: SPONGE; Potency: ADJ PHSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION; Potency: ADJ PHSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION; Potency: ADJ PHSource →
  • EUCosIngActiveD-Glucono-1,5-lactone
  • GLOBALJECFANOT SPECIFIEDJECFA evaluation lists ADI NOT SPECIFIED. Functional class: acid, acidity regulator, raising agent, sequestrant.
    • JECFA evaluation lists ADI NOT SPECIFIED. Functional class: acid, acidity regulator, raising agent, sequestrant.Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record.
  • USEPAcommercial use observedEPA CPDat observed this chemical in 1370 composition records across product categories including Laboratory supplies, Personal care, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Chelating agent.
    • EPA CPDat observed this chemical in 1370 composition records across product categories including Laboratory supplies, Personal care, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, Chelating agent.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
    • FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI NOT SPECIFIED. Functional class: acid, acidity regulator, raising agent, sequestrant.

      Year not recorded · GLOBAL JECFA listing · Read the source →

    • JECFA evaluation record.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Gluconolactone yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2026-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (2)
Openfda substance

codexalimentarius.net

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Gluconolactone in a product composition. These are source records, not Greenveil catalog products.

Source records

1,370

Named organisations

6

Laboratory suppliesPersonal careCleaning products and household care

Typical roles

Skin conditioningChelatingAcid, acidity regulator, raising agent, sequestrantAntioxidantPreservativeHumectant
See products using Gluconolactone →

Catalog

Found in these products

Their ingredient lists include Gluconolactone; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 200 →Find products without it →