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1,3,5-Trimethoxybenzene

CAS 621-23-8

1,3,5-Trimethoxybenzene chemical structure

Concern score

Not assessed — no hazard data yet.

1,3,5-Trimethoxybenzene in plain language

What it is

On cosmetic ingredient lists it appears as “Phloroglucinol trimethyl ether”.

Also known as Phloroglucinol trimethyl ether · Trimethylphloroglucinol · 1,3,5-Trimethoxy benzene · 1,3,5-Trimethoxybenzol · 1,3,5-Trimethyoxybenzene · 1,5-Trimethoxybenzene

Show all 12 names

Benzene, 1,3,5-trimethoxy- · CAS-621-23-8 · NCGC00095239-01 · O,O,O-1,3,5-Trimethylresorcinol · UNII-00VJI3VG3D · sym-trimethoxybenzene

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
  • Fragrance
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. 1,3,5-Trimethoxybenzene appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 13 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Fragrance.
    • EPA CPDat observed this chemical in 13 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Fragrance.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for 1,3,5-Trimethoxybenzene. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for 1,3,5-Trimethoxybenzene yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated November 2014

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

nikkajiweb.jst.go.jp

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed 1,3,5-Trimethoxybenzene in a product composition. These are source records, not Greenveil catalog products.

Source records

13

Named organisations

4

Personal care

Typical roles

Skin conditioningFragranceConditioner
See products using 1,3,5-Trimethoxybenzene →