# LOPERAMIDE HYDROCHLORIDE

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid00880006
Categories: food, pharma
Identifier: DTXSID00880006

> LOPERAMIDE HYDROCHLORIDE. EPA CPDat observed this chemical in 1 composition records across product categories including Food and drug. Compiled from 6 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet.
- Rationale: EPA CPDat observed this chemical in 1 composition records across product categories including Food and drug.

## Regulatory status

- US: commercial use observed — EPA CPDat observed this chemical in 1 composition records across product categories including Food and drug.
- US: marketed drug occurrence — FDA NDC lists this ingredient in 227 active drug products and 230 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- JECFA (Joint FAO/WHO Expert Committee on Food Additives): no opinion on file.
- EFSA (European Food Safety Authority): no opinion on file.

## Data sources

- EPA Chemical and Products Database (updated 2019-03-06): http://siri.org/msds/f2/cgj/cgjhq.html
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA National Drug Code Directory (updated 2028-01-31): https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory-support-files
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:77TI35393C
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/71420

_Assessed by Greenveil._