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Trimethylpentyl polysilsesquioxane

CAS 190732-67-3

Also registered as 1 other CAS number

444619-08-3

Concern score

Not assessed — no hazard data yet.

Trimethylpentyl polysilsesquioxane in plain language

What it does

Used in cosmetics as a nail conditioning agent.

  • Nail conditioning
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

What we know about this ingredient

EPA DSSTox provides the canonical identifier, structure, and synonym profile for this chemical.

Regulation

No restrictions found. Trimethylpentyl polysilsesquioxane appears in these published regulatory listings.

  • EUCosIngActiveTrimethylpentyl Polysilsesquioxane is a resinous material composed of a mixture of three-dimensional siloxane polymers and oligomers with cage structures. For the oligomers, each silicon atom in the polysilsesquioxane is connected via oxygen atoms to three other silicon atoms and can be represented by the empirical formulation RSiO3/2 where R represents the trimethylpentyl group. For the larger polymeric polysilsesquioxanes, some of the silicon atoms are not connected to other silicon atoms and instead have a silanol (SiOH) group. Trimethylpentyl Polysilsesquioxane is prepared by the hydrolysis and condensation of 2,4,4-trimethylpentyl trimethoxysilane
    • Trimethylpentyl Polysilsesquioxane is a resinous material composed of a mixture of three-dimensional siloxane polymers and oligomers with cage structures. For the oligomers, each silicon atom in the polysilsesquioxane is connected via oxygen atoms to three other silicon atoms and can be represented by the empirical formulation RSiO3/2 where R represents the trimethylpentyl group. For the larger polymeric polysilsesquioxanes, some of the silicon atoms are not connected to other silicon atoms and instead have a silanol (SiOH) group. Trimethylpentyl Polysilsesquioxane is prepared by the hydrolysis and condensation of 2,4,4-trimethylpentyl trimethoxysilaneSource →

Expert safety opinions

No expert opinion on file for Trimethylpentyl polysilsesquioxane. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Trimethylpentyl polysilsesquioxane yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

2 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.