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Niacin

CAS 101113-41-1 · 40/100 · High conf.

Also registered as 3 other CAS numbers

123574-58-3 · 1580002-26-1 · 59-67-6

Niacin chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Niacin in plain language

What it is

Also known as Nicotinic acid · Vitamin B3 · Niacin extended release · Pyridine-3-carboxylic acid · 3-Carboxylpyridine · 3-Carboxypyridine

Show all 32 names

3-Pyridinecarboxylic acid · 3-Pyridylcarboxylic acid · Acide nicotinique · Akotin · Apelagrin · Daskil · Efacin · Linic · Niacor · Niaspan · Nicolar · Nicacid · Nicangin · Niconacid · Nicotinipca · Nyclin · Pellagrin · Pelonin · Vitamin B-3 · Vitamin B3 (niacin or nicotinic acid) · Wampocap · acido nicotinico · nicotinate · Advicor component niacin · Simcor component niacin · acidum nicotinicum

What it does

Used in cosmetics as a smoothing agent and an antistatic agent.

  • Smoothing
  • Antistatic
  • Humectant
  • Flavouring
  • Conditioner
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 187 composition records across product categories including Laboratory supplies, Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Niacin appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Industrial
  • EUEFSAEFSA opinion8 entries
    • Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as feed additive for all animal species based on a dossier submitted by Agrinutrition BV (EFSA FEEDAP)Source →
    • Inositol hexanicotinate (inositol hexaniacinate) as a source of niacin (vitamin B3) added for nutritional purposes in food supplements (EFSA ANS)Source →
    • Mixture of chromium di- and tri-nicotinate as a source of chromium added for nutritional purposes in food supplements and in foods for particular nutritional uses (EFSA ANS)Source →
    • Scientific Opinion on Dietary Reference Values for niacin (EFSA NDA)Source →
    • Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG (EFSA FEEDAP)Source →
    • Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Vertellus Specialties Belgium BV (EFSA FEEDAP)Source →
    • Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Lonza Benelux BV (EFSA FEEDAP)Source →
    • Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as a feed additive for all animal species based on a dossier submitted by EUROPE-ASIA Import Export GmbH (EFSA FEEDAP)Source →
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • EUEFSAReport from international authorityOpinion of the Scientific Committee on Food on the Tolerable Upper Intake Levels of Nicotinic Acid and Nicotinamide (Niacin) (SCF)
    • Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Levels of Nicotinic Acid and Nicotinamide (Niacin) (SCF)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 187 composition records across product categories including Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Humectant, Softener and conditioner.
    • EPA CPDat observed this chemical in 187 composition records across product categories including Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Anti-static agent, Humectant, Softener and conditioner.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 66 active drug products and 67 total products.
    • FDA NDC lists this ingredient in 66 active drug products and 67 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Opinion of the Scientific Committee on Food on the Tolerable Upper Intake Levels of Nicotinic Acid and Nicotinamide (Niacin) (SCF)

      2002 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as feed additive for all animal species based on a dossier submitted by Agrinutrition BV (EFSA FEEDAP)

      2012 · EU EFSA listing · Read the source →

    • Inositol hexanicotinate (inositol hexaniacinate) as a source of niacin (vitamin B3) added for nutritional purposes in food supplements (EFSA ANS)

      2009 · EU EFSA listing · Read the source →

    • Mixture of chromium di- and tri-nicotinate as a source of chromium added for nutritional purposes in food supplements and in foods for particular nutritional uses (EFSA ANS)

      2008 · EU EFSA listing · Read the source →

    • Scientific Opinion on Dietary Reference Values for niacin (EFSA NDA)

      2014 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by VITAC EEIG (EFSA FEEDAP)

      2012 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Vertellus Specialties Belgium BV (EFSA FEEDAP)

      2012 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of niacin (nicotinic acid and nicotinamide) as a feed additive for all animal species based on a dossier submitted by Lonza Benelux BV (EFSA FEEDAP)

      2012 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of niacin (nicotinamide) as a feed additive for all animal species based on a dossier submitted by EUROPE-ASIA Import Export GmbH (EFSA FEEDAP)

      2012 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Niacin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →
  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2028-04-27

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

accessdata.fda.gov

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Niacin in a product composition. These are source records, not Greenveil catalog products.

Source records

187

Named organisations

6

Laboratory suppliesPersonal care

Typical roles

SmoothingAntistaticHumectantFlavouringConditioner
See products using Niacin →

Catalog

Found in these products

Their ingredient lists include Niacin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.