beauty
cleaning
industrial
pharma

Melatonin

CAS 8041-44-9

Also registered as 3 other CAS numbers

942407-96-7 · 1581233-31-9 · 73-31-4

Concern score

Not assessed — no hazard data yet.

Melatonin in plain language

What it is: Also known as 5-METHOXY n-acetyl-tryptamine · Melatonine · 3-(2-Acetamidoethyl)-5-methoxyindole · 5-Methoxy-N-acetyltryptamine · Acetamide, N-(2-(5-methoxyindol-3-yl)ethyl)- · BCI-049
Show all 15 names
Circadin · J5.258B · Melatol · Melovine · Melapure · N-(2-(5-Methoxyindol-3-yl)ethyl)acetamide · N-Acetyl-5-methoxytryptamine · N-acetyl-5-methoxy-tryptamine · Regulin
What it does: Used in cosmetics as an antioxidant.
Antioxidant
Is it a concern?: We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Melatonin appears in these published regulatory listings.

In marketed US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Industrial

EUCosIngActiveMelatonin is the organic compound that conforms to the formula
- Melatonin is the organic compound that conforms to the formulaSource →
USEPAcommercial use observedEPA CPDat observed this chemical in 20 composition records across product categories including Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Antioxidant.
- EPA CPDat observed this chemical in 20 composition records across product categories including Personal care, Raw materials. EPA CPDat classifies this chemical for functional uses including Antioxidant.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 42 active drug products and 49 total products.
- FDA NDC lists this ingredient in 42 active drug products and 49 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Melatonin. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Melatonin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated June 2016
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA National Drug Code Directory
regulatory · updated 2028-10-03
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

nikkajiweb.jst.go.jp

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often FDA National Drug Code directory has listed Melatonin in a product composition. These are source records, not Greenveil catalog products.

Source records

Typical roles

Antioxidant

See products using Melatonin →

Catalog

Found in these products

Their ingredient lists include Melatonin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 31 →Find products without it →