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Hydroxyproline

CAS 6912-67-0

Also registered as 8 other CAS numbers

618-28-0 · 147028-80-6 · 138-46-5 · 17210-41-2 · 21105-75-9 · 24784-87-0 · 54733-36-7 · 51-35-4

Hydroxyproline chemical structure

Concern score

Not assessed — no hazard data yet.

Hydroxyproline in plain language

What it is

Also known as L-Hydroxyproline · (2S,4R)-4-hydroxypyrrolidine-2-carboxylic acid · (4R)-4-Hydroxy-L-proline · Hyp · (2S,4R)-4-HYDROXYPROLINE · (2S,4R)-4-hydroxy-2-pyrrolidinecarboxylic acid

Show all 20 names

4-HYDROXY-L-PROLINE · 4-HYDROXYPROLINE · 4-Hydroxy-2-pyrrolidinecarboxylic acid · Hypro · L-4-hydroxyproline · L-proline, 4-HYDROXY-, trans- · L-Proline, 4-hydroxy-, (4R)- · L-threo-4-hydroxyproline · Lumistor · delta-Hydroxyproline · hydroxy-L-proline · trans-4-Hydroxy-L-proline · trans-Hydroxyproline · trans-L-Hydroxyproline

What it does

Used in cosmetics as a skin-conditioning agent, a hair conditioner and a cleansing agent.

  • Skin conditioning
  • Hair conditioning
  • Cleansing
  • Antistatic
  • Surfactant
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Hydroxyproline appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Industrial
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 37 composition records across product categories including Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Surfactant (surface active agent), Anti-static agent, Softener and conditioner.
    • EPA CPDat observed this chemical in 37 composition records across product categories including Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including Surfactant (surface active agent), Anti-static agent, Softener and conditioner.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Hydroxyproline. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Hydroxyproline yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Hydroxyproline in a product composition. These are source records, not Greenveil catalog products.

Source records

37

Named organisations

6

Laboratory suppliesPersonal care

Typical roles

Skin conditioningHair conditioningCleansingAntistaticSurfactantConditioner
See products using Hydroxyproline →

Catalog

Found in these products

Their ingredient lists include Hydroxyproline; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 27 →Find products without it →