Skip to content

GREENVEIL

  • beauty
  • cleaning
  • pharma

Acetyl HEXAPEPTIDE-8

CAS 616204-22-9

Acetyl HEXAPEPTIDE-8 chemical structure

Concern score

Not assessed — no hazard data yet.

Acetyl HEXAPEPTIDE-8 in plain language

What it is

Also known as Acetyl hexapeptide-3 · Acetyl HEXAPEPTIDE-8 amide · Argireline acetate · Argireline · AC-28736 · AC-GLU-GLU-MET-GLN-ARG-ARG-NH2

Show all 22 names

AC8712 · AKOS015994631 · Argreline acetate · Acetyl Hexapeptide-3(Argireline) · Acetyl-glu-glu-met-gln-arg-arg-amide · Argireline Acetate anti-aging cosmetic peptide · Argreline · C34H60N14O12S · CS-5101 · EX-A6258 · HS-2002 · HY-P0033 · Hexapeptide 3 · Rjznprojtjsylc-llinqdlysa-n · TP1253 · acetyl hexapeptide-24 amide

What it does

Used in cosmetics as a humectant and a skin-conditioning agent.

  • Humectant
  • Skin conditioning
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Acetyl HEXAPEPTIDE-8 appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • EUCosIngActiveAcetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residues
    • Acetyl hexapeptide-8 is the synthetic peptide consisting of arginine, methionine, and acetylated glutamic acid residuesSource →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 20 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner.
    • EPA CPDat observed this chemical in 20 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 6 active drug products and 6 total products.
    • FDA NDC lists this ingredient in 6 active drug products and 6 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as protein.
    • openFDA substance registry classifies this ingredient as protein.Source →

Expert safety opinions

No expert opinion on file for Acetyl HEXAPEPTIDE-8. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Acetyl HEXAPEPTIDE-8 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated November 2015

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (2)
Openfda substance

cellularskinrx.com

Read →
Openfda substance

www3.interscience.wiley.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Acetyl HEXAPEPTIDE-8 in a product composition. These are source records, not Greenveil catalog products.

Source records

20

Named organisations

6

Personal care

Typical roles

HumectantSkin conditioningConditioner
See products using Acetyl HEXAPEPTIDE-8 →

Catalog

Found in these products

Their ingredient lists include Acetyl HEXAPEPTIDE-8; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 33 →Find products without it →