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1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE

CAS 18603-43-5

Also registered as 3 other CAS numbers

81534-16-9 · 82617-24-1 · 816-94-4

1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE chemical structure

Concern score

Not assessed — no hazard data yet.

1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE in plain language

What it is

On cosmetic ingredient lists it appears as “Distearoyl glycerophosphocholine”.

Also known as Distearoyl glycerophosphocholine · 1,2-Distearoyl-sn-3-phosphacholine · 1,2-DIASTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE · 1,2-DISTEARIN SN-3-PHOSPHORYLCHOLINE · 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE (dspc) · Distearoyl-l-.alpha.-lecithin

Show all 20 names

DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE · Dspc · Dspc r-isomer · L-distearoyllecithin · 1,2-Bis(stearoyl)-sn-glycero-3-phosphocholine · 1,2-Dioctadecanoyl-sn-glycero-3-phosphocholine · 1,2-Distearoyl-3-sn-phosphatidylcholine · 1,2-Distearoyl-L-α-glycerophosphocholine · 1,2-distearoyllecithin, (R)- · Dspc r- · Distearoyl phosphatidylcholine · L-dspc · PC(18:0/18:0) · PC(36:0)

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • USFDAinactive ingredient database4 entries — 2 administration routes
    • Route: INTRAVENOUS; Dosage form: INJECTABLE, LIPOSOMAL; Potency: 2.8 %w/vSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 68 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SUSPENSION; Potency: NASource →
    • Route: RESPIRATORY (INHALATION); Dosage form: CAPSULE; Maximum daily exposure: 51 mgSource →
  • EUCosIngActiveDistearoyl Glycerophosphocholine
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
    • FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated 2019-12-20

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

avantilipids.com

Read →

Allergen profile

Canonical allergen markers detected on this ingredient. Each row is derived from the ingredient’s name or synonyms matching a known allergen class — useful when scanning a label for a specific allergy context.

  • SoyContains · Oral (ingested)

    Source: chemindex_name_match

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often FDA National Drug Code directory has listed 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE in a product composition. These are source records, not Greenveil catalog products.

Source records

2

Typical roles

Skin conditioningConditioner
See products using 1,2-DISTEAROYL-SN-GLYCERO-3-PHOSPHOCHOLINE →