beauty
cleaning
food
industrial

Tromethamine

CAS 79261-03-3

Also registered as 13 other CAS numbers

126850-03-1 · 126850-05-3 · 126850-06-4 · 126850-08-6 · 136760-04-8 · 25149-07-9 · 68755-45-3 · 83147-39-1 · 108195-86-4 · 119320-15-9 · 857365-23-2 · 1158650-64-6 · 77-86-1

Concern score

Not assessed — no hazard data yet.

Tromethamine in plain language

What it is: Also known as Trometamol · Tris(hydroxymethyl)aminomethane · 2-Amino-2-(hydroxymethyl)propane-1,3-diol · Tham · Tris · Tris-base
Show all 29 names
Trizma · 1,3-Propanediol, 2-amino-2-(hydroxymethyl)- · 2-AMINO-2-(HYDROXYMETHYL)-1,3-PROPANDIOL · 2-Amino-1,3-dihydroxy-2-(hydroxymethyl)propane · 2-Amino-2-(hydroxymethyl)-1,3-propanediol · 2-Amino-2-hydroxymethylpropan-1,3-diol · Addex-tham · Aminotrimethylolmethane · Pehanorm · Talatrol · Trimethylolaminomethane · Tris Amino · Tris buffer · free base Tris · Tris-steril · Trisamine · Trisaminol · Trispuffer · Tromethane · Tutofusin tris · tris base · tris-hydroxymethylaminomethane · Tham-e component tromethamine
What it does: Used in cosmetics as a pH buffer and a fragrance ingredient.
Buffering
Fragrance
pH adjuster
Deodorant
Is it a concern?: We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Tromethamine appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Pharma
Food
Industrial

USFDAinactive ingredient database28 entries — 14 administration routes
- Route: ENDOTRACHEAL; Dosage form: SUSPENSION; Potency: 2.42 mgSource →
- Route: INTRA-ARTERIAL; Dosage form: INJECTION; Maximum daily exposure: 562 mgSource →
- Route: INTRA-ARTERIAL; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 300 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 437 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Potency: 1.21 %w/vSource →
- Route: INTRATHECAL; Dosage form: SOLUTION; Potency: 0.12 %w/vSource →
- Route: INTRATYMPANIC; Dosage form: SUSPENSION; Maximum daily exposure: 2 mgSource →
- Route: INTRAVASCULAR; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 225 mgSource →
- Route: INTRAVASCULAR; Dosage form: SOLUTION; Potency: 0.12 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 1134 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SUSPENSION; Potency: 6.06 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION; Potency: 0.24 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 300 mgSource →
- Route: INTRAVENOUS; Dosage form: SOLUTION; Potency: 0.12 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 0.75 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION, GEL FORMING / DROPS; Maximum daily exposure: 1 mgSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION, GEL FORMING, EXTENDED RELEASE; Potency: 0.8 %w/wSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Potency: 0.8 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Potency: ADJ PHSource →
- Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 30 mgSource →
- Route: ORAL; Dosage form: SOLUTION; Potency: 1.21 mg/1mlSource →
- Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 30 mgSource →
- Route: RECTAL; Dosage form: SOLUTION; Potency: 0.12 %w/vSource →
- Route: RESPIRATORY (INHALATION); Dosage form: SOLUTION; Potency: 0.01 %w/vSource →
- Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 56 mgSource →
- Route: TOPICAL; Dosage form: SOLUTION; Potency: 8.4 %w/wSource →
- Route: TRANSDERMAL; Dosage form: GEL; Maximum daily exposure: 10 mgSource →
- Route: URETHRAL; Dosage form: SOLUTION; Potency: 0.12 %w/vSource →
EUCosIngActiveRestriction: III/61
- Restriction: III/61Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 731 composition records across product categories including Food and drug, Laboratory supplies, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Deodorizer, pH regulating agent, Fragrance.
- EPA CPDat observed this chemical in 731 composition records across product categories including Food and drug, Laboratory supplies, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Deodorizer, pH regulating agent, Fragrance.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 3 active drug products and 5 total products.
- FDA NDC lists this ingredient in 3 active drug products and 5 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Tromethamine. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Tromethamine yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated may 31, 2015
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2028-03-09
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Allergen profile

Canonical allergen markers detected on this ingredient. Each row is derived from the ingredient’s name or synonyms matching a known allergen class — useful when scanning a label for a specific allergy context.

SoyContains · Oral (ingested)
Source: chemindex_name_match

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Tromethamine in a product composition. These are source records, not Greenveil catalog products.

Source records

731

Named organisations

Food and drugLaboratory suppliesCleaning products and household carePersonal careIndustrial products

Typical roles

BufferingFragrancepH adjusterDeodorant

See products using Tromethamine →

Catalog

Found in these products

Cosmetic and personal-care products that list Tromethamine are shown first. Their ingredient lists include Tromethamine; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 85 →Find products without it →