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  • cleaning
  • food
  • industrial
  • pharma

Hexamethyldisilazane

CAS 999-97-3

Also registered as 6 other CAS numbers

27495-70-1 · 18186-75-9 · 103737-28-6 · 116638-29-0 · 127290-38-4 · 761458-30-4

Hexamethyldisilazane chemical structure

Concern score

Not assessed — no hazard data yet.

Hexamethyldisilazane in plain language

What it is

Also known as 1,1,1-Trimethyl-N-(trimethylsilyl)silanamine · Hmds · (TMS)2NH · 1,1,1,3,3,3-Hexamethyldisilazan · 1,1,1,3,3,3-Hexamethyldisilazane · 1,1,1,3,3,3-hexametildisilazano

Show all 16 names

Di(trimethylsilyl)amine · Disilazane, 1,1,1,3,3,3-hexamethyl- · Hexamethylsilazane · Sz 6079 · Silanamine, 1,1,1-trimethyl-N-(trimethylsilyl)- · Tsl 8802 · bis(trimethylsilyl)amine · hexamethyl disilazane · hexamethyldisilylamine · sodium hexamethyldisilazide

What it does

Used in consumer products as a thickener.

  • Thickener
Is it a concern?
We haven't assessed a concern score for this ingredient yet.

Regulation

No restrictions found. Hexamethyldisilazane appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • USEPAcommercial use observedEPA CPDat observed this chemical in 15 composition records across product categories including Industrial products, Home maintenance, Food and drug. EPA CPDat classifies this chemical for functional uses including Thickening agent.
    • EPA CPDat observed this chemical in 15 composition records across product categories including Industrial products, Home maintenance, Food and drug. EPA CPDat classifies this chemical for functional uses including Thickening agent.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Hexamethyldisilazane. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    No JECFA evaluation on file.

  • EFSA

    European Food Safety Authority

    No EFSA opinion on file.

Evidence & sources

No graded research studies for Hexamethyldisilazane yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

5 data sources

Where this comes from

  • EPA Chemical and Products Database

    exposure · updated january 23, 2020

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Hexamethyldisilazane in a product composition. These are source records, not Greenveil catalog products.

Source records

15

Named organisations

3

Industrial productsHome maintenanceFood and drugLaboratory suppliesCleaning and safety

Typical roles

Thickener
See products using Hexamethyldisilazane →