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Calcium gluconate

CAS 3414-35-5 · 40/100 · High conf.

Also registered as 2 other CAS numbers

18016-24-5 · 299-28-5

Calcium gluconate chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Calcium gluconate in plain language

What it is

Also known as Calcium gluconate anhydrous · Anhydrous calcium gluconate · Calcium D-gluconate · Calcarea gluconica · Calcium di-gluconate · Calcium di(D-gluconate)

Show all 27 names

D-gluconic acid, calcium salt (2:1) · calcium bis((2R,3S,4R,5R)-2,3,4,5,6-pentahydroxyhexanoate) · Calglucon · Calcicol · Calciofon · Calcipur · Calcium hexagluconate · Calciumgluconat · Calglucol · Dragocal · E-578 · Ebucin · Glucobiogen · Gluconate de calcium · Gluconato di calcio · Ins NO.578 · INS-578 · Kalpren · Novocal · calcium ketogluconate · calcii gluconas

What it does

Used in cosmetics as a skin-conditioning agent and a chelating agent. Calcium Gluconate is the calcium salt of gluconic acid.

  • Skin conditioning
  • Chelating
  • Acidity regulator, firming agent, nutrient supplement, sequestrant
  • Humectant
  • Chelating agent
  • Thickener
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 378 composition records across product categories including Food and drug, Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Calcium gluconate appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • EUCosIngActiveCalcium Gluconate is the calcium salt of gluconic acid that conforms to the formula:
    • Calcium Gluconate is the calcium salt of gluconic acid that conforms to the formula:Source →
  • GLOBALJECFANOT SPECIFIEDJECFA evaluation lists ADI NOT SPECIFIED. Functional class: acidity regulator, firming agent, nutrient supplement, sequestrant.
    • JECFA evaluation lists ADI NOT SPECIFIED. Functional class: acidity regulator, firming agent, nutrient supplement, sequestrant.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 378 composition records across product categories including Food and drug, Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, oral care.
    • EPA CPDat observed this chemical in 378 composition records across product categories including Food and drug, Personal care. EPA CPDat classifies this chemical for functional uses including Humectant, Softener and conditioner, oral care.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 4 active drug products and 7 total products.
    • FDA NDC lists this ingredient in 4 active drug products and 7 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI NOT SPECIFIED. Functional class: acidity regulator, firming agent, nutrient supplement, sequestrant.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Calcium gluconate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2029-01-04

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (2)
Openfda substance

codexalimentarius.net

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Calcium gluconate in a product composition. These are source records, not Greenveil catalog products.

Source records

378

Named organisations

6

Food and drugPersonal care

Typical roles

Skin conditioningChelatingAcidity regulator, firming agent, nutrient supplement, sequestrantHumectantChelating agentThickener
See products using Calcium gluconate →

Catalog

Found in these products

Their ingredient lists include Calcium gluconate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 109 →Find products without it →