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3-Mercaptopropyltrimethoxysilane

CAS 29295-80-5

Also registered as 7 other CAS numbers

53241-23-9 · 56938-96-6 · 89468-78-0 · 161756-15-6 · 383189-28-4 · 1818863-79-4 · 4420-74-0

3-Mercaptopropyltrimethoxysilane chemical structure

Concern score

Not assessed — no hazard data yet.

3-Mercaptopropyltrimethoxysilane in plain language

What it is

On cosmetic ingredient lists it appears as “Mercaptopropyltrimethoxysilane”.

Also known as Mercaptopropyltrimethoxysilane · (3-MERCAPTOPROPYL)TRIMETHOXYSILANE · 3-(Trimethoxysilyl)propane-1-thiol · 3-MPTMS · 3-trimethoxysilylpropane-1-thiol · (3-MERCAPTOPROPYL)-TRIMETHOXY-SILAN

Show all 28 names

(3-Thiopropyl)trimethoxysilane · (gamma-mercaptopropyl)trimethoxysilane · (γ-Mercaptopropyl)trimethoxysilane · 1-Propanethiol, 3-(trimethoxysilyl)- · 3-(Sulfanylpropyl)trimethoxysilane · 3-(TRIMETHOXYSILYL)PROPYL mercaptan · 3-(Trimethoxysilyl)-1-propanethiol · 3-(trimethoxysilyl)propanethiol · 3-MERCAPTOPROPYL trimethoxylsilane · A 189 (silicone) · Az 6129 · Gf 70 · Kbe 803 · Kbm 803 · M 8500 (coupling agent) · Nuca 189 · Prosil 196 · Silane A 189 · Silquest A 189 · Tsl 8380 · TSL8380E · organosilane

What it does

Used in cosmetics as a nail conditioning agent.

  • Nail conditioning
  • Antioxidant
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. 3-Mercaptopropyltrimethoxysilane appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUCosIngActiveMercaptopropyltrimethoxysilane is the organic compound
    • Mercaptopropyltrimethoxysilane is the organic compoundSource →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 18 composition records across product categories including Raw materials, Home maintenance, Industrial products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Antioxidant, Filler.
    • EPA CPDat observed this chemical in 18 composition records across product categories including Raw materials, Home maintenance, Industrial products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Antioxidant, Filler.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for 3-Mercaptopropyltrimethoxysilane. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for 3-Mercaptopropyltrimethoxysilane yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA Chemical and Products Database

    exposure · updated 2021-06-08

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed 3-Mercaptopropyltrimethoxysilane in a product composition. These are source records, not Greenveil catalog products.

Source records

18

Named organisations

6

Raw materialsHome maintenanceIndustrial products

Typical roles

Nail conditioningAntioxidantConditioner
See products using 3-Mercaptopropyltrimethoxysilane →