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Levomefolate calcium

CAS 129025-21-4 · 40/100 · High conf.

Also registered as 1 other CAS number

151533-22-1

Levomefolate calcium chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Levomefolate calcium in plain language

What it is

Also known as Calcium levomefolate · 6(S)-5-METHYLTETRAHYDROFOLIC acid, calcium salt · Calcium L-5-METHYLTETRAHYDROFOLATE · L-5-METHYLTETRAHYDROFOLIC acid, calcium salt · L-5-MTHF-Ca · Calcium l-methylfolate

Show all 21 names

(6S)-5-METHYLTETRAHYDROFOLIC acid calcium salt · Bodyfolin · CALCIUM-5-METHYLTETRAHYDROFOLATE · L-5-METHYLTETRAHYDROFOLATE calcium · L-methylfolate-calcium · Levomefolinate calcium · C20H23CaN7O6 · Extrafolate-s · L186860 · Lmc-a · Lmca · Levomefolic acid calcium salt · Metafolin · Beyaz component levomefolate calcium · Safyral component levomefolate calcium

What it does

Used in food as a nutrient supplement.

  • Nutrient supplement
Is it a concern?
Moderate concern: no hazard classifications on record.

Why it's flagged

EPA DSSTox provides the canonical identifier, structure, and synonym profile for this chemical.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Levomefolate calcium appears in these published regulatory listings.

  • EUEFSAEFSA opinion2 entries
    • Calcium L-methylfolate as a source of folate added for nutritional purposes to infant and follow-on formula, baby food and processed cereal-based food (EFSA NDA)Source →
    • Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Calcium L-Methylfolate (EFSA AFC)Source →
  • GLOBALJECFANO SAFETY CONCERNJECFA evaluation lists ADI NO SAFETY CONCERN. Functional class: nutrient supplement.
    • JECFA evaluation lists ADI NO SAFETY CONCERN. Functional class: nutrient supplement.Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record.
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI NO SAFETY CONCERN. Functional class: nutrient supplement.

      Year not recorded · GLOBAL JECFA listing · Read the source →

    • JECFA evaluation record.

      Year not recorded · GLOBAL JECFA listing · Read the source →

  • EFSA

    European Food Safety Authority

    • Calcium L-methylfolate as a source of folate added for nutritional purposes to infant and follow-on formula, baby food and processed cereal-based food (EFSA NDA)

      2020 · EU EFSA listing · Read the source →

    • Opinion of the Scientific Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) related to Calcium L-Methylfolate (EFSA AFC)

      2004 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Levomefolate calcium yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

cfsanappsexternal.fda.gov

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Catalog

Found in these products

Their ingredient lists include Levomefolate calcium; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 50 →Find products without it →