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Piperine

CAS 7780-20-3 · 40/100 · High conf.

Also registered as 2 other CAS numbers

147030-08-8 · 94-62-2

Piperine chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Piperine in plain language

What it is

Also known as (E,E)-piperidine · Bioperine · (E,E)-1-piperoylpiperidine · 1-Piperoyl-piperidine · 1-Piperoylpiperidine · Piperin

Show all 9 names

Piperine 1537 · Piperoylpiperidine · Piperine (constituent of black pepper)

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
  • Flavouring agent
  • Fragrance
  • Flavouring
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Piperine appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEFSAEFSA opinion3 entries
    • Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting) (EFSA CEF)Source →
    • Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) (EFSA CEF)Source →
    • Flavouring Group Evaluation 86, (FGE.86): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting). Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)Source →
  • EUCosIngActivePiperine is the organic compound that conforms to the formula
    • Piperine is the organic compound that conforms to the formulaSource →
  • GLOBALJECFANo safety concern at current levels of intake when used as a flavouring agentJECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
    • JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Fragrance, Flavouring and nutrient.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 4 active drug products and 5 total products.
    • FDA NDC lists this ingredient in 4 active drug products and 5 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Scientific Opinion on Flavouring Group Evaluation 86, Revision 2 (FGE.86Rev2): Consideration of aliphatic and arylalkyl amines and amides evaluated by JECFA (65th meeting) (EFSA CEF)

      2015 · EU EFSA listing · Read the source →

    • Scientific Opinion on Flavouring Group Evaluation 86, Revision 1 (FGE.86Rev1): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting) (EFSA CEF)

      2011 · EU EFSA listing · Read the source →

    • Flavouring Group Evaluation 86, (FGE.86): Consideration of aliphatic and aromatic amines and amides evaluated by JECFA (65th meeting). Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)

      2008 · EU EFSA listing · Read the source →

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Piperine yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated February 8, 2019

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2029-01-04

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often FDA National Drug Code directory has listed Piperine in a product composition. These are source records, not Greenveil catalog products.

Source records

5

Typical roles

Skin conditioningFlavouring agentFragranceFlavouring
See products using Piperine →

Catalog

Found in these products

Their ingredient lists include Piperine; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 44 →Find products without it →