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Hyaluronate sodium

CAS 34448-35-6 · 40/100 · High conf.

Also registered as 3 other CAS numbers

1319723-90-4 · 1430231-35-8 · 9067-32-7

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Hyaluronate sodium in plain language

What it is

On cosmetic ingredient lists it appears as “Sodium hyaluronate”.

Also known as Sodium hyaluronate · Hyaluronic acid sodium salt · Hyaluronan sodium · Hyruan plus · Arthrease · Artz Dispo

Show all 14 names

Bio Hyaluro 12 · Chlamyhyaluronic acid sodium salt · Healon (polysaccharide) · Hyaluronic acid, sodium, salt · Legend · Ostenil · hyaluronic acid sodium · Sodium hyaluronate for ir identification

What it does

Used in cosmetics as a humectant and a skin-conditioning agent.

  • Humectant
  • Skin conditioning
  • Conditioner
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 4595 composition records across product categories including Personal care, Construction, Food and drug.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Hyaluronate sodium appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial
  • USFDAinactive ingredient database5 entries — 4 administration routes
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 23 mgSource →
    • Route: INTRAVITREAL; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 23 mgSource →
    • Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 463 mgSource →
    • Route: INTRA-ARTICULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 23 mgSource →
    • Route: TOPICAL; Dosage form: LOTION; Potency: 0.01 %w/wSource →
  • USFDAmarketed drug occurrence2 entries
    • FDA NDC lists this ingredient in 3 active drug products and 4 total products.Source →
    • FDA NDC lists this ingredient in 11 active drug products and 11 total products.Source →
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • EUEFSAEFSA statementInability to assess the safety of sodium hyaluronate added for nutritional purposes as a source of sodium in food supplements and the bioavailability of sodium from this source, based on the supporting dossier (EFSA ANS)
    • Inability to assess the safety of sodium hyaluronate added for nutritional purposes as a source of sodium in food supplements and the bioavailability of sodium from this source, based on the supporting dossier (EFSA ANS)Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 4595 composition records across product categories including Personal care, Construction, Food and drug. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Humectant.
    • EPA CPDat observed this chemical in 4595 composition records across product categories including Personal care, Construction, Food and drug. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, Humectant.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as polymer.
    • openFDA substance registry classifies this ingredient as polymer.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Inability to assess the safety of sodium hyaluronate added for nutritional purposes as a source of sodium in food supplements and the bioavailability of sodium from this source, based on the supporting dossier (EFSA ANS)

      2009 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Hyaluronate sodium yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2019

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →
Reference links (3)
Openfda substance

clinicaltrials.gov

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Hyaluronate sodium in a product composition. These are source records, not Greenveil catalog products.

Source records

4,595

Named organisations

6

Personal careConstructionFood and drugBatteriesCleaning products and household careRaw materials

Typical roles

HumectantSkin conditioningConditioner
See products using Hyaluronate sodium →

Catalog

Found in these products

Their ingredient lists include Hyaluronate sodium; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Hyaluronate sodium in the catalog.