beauty
cleaning
food

Neohesperidin dihydrochalcone

CAS 71552-53-9 · 60/100 · High conf.

Also registered as 1 other CAS number

20702-77-6

Neohesperidin dihydrochalcone chemical structure

Concern score

60/100High concern based on regulatory listings.

High confidence

Neohesperidin dihydrochalcone in plain language

What it is: Also known as Neohesperidine dihydrochalcone · Neohesperidin dihydrochalone · Neohesperidin-dihydrochalcone · Hesperetin DIHYDROCHALCONE-4'-.BETA.-NEOHESPERIDOSIDE · Neohesperidin dc · Neohesperidine dc
Show all 13 names
Nhdc · C28H36O15 · Citrosa · NCI-C60764 · Neohesperidin dhc · Neohesperidin dihydrochalcone hydrate · Neosperidin dihydrochalcone
What it does: Used in cosmetics as a flavouring and a fragrance ingredient.
Flavouring
Perfuming
Fragrance
Sweetener
Deodorant
Is it a concern?: High concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 26 composition records across product categories including Personal care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Neohesperidin dihydrochalcone appears in these published regulatory listings.

Recorded in these product areas

Found in consumer products
Beauty
Cleaning

EUEFSAEFSA opinion3 entries
- Scientific Opinion on the safety of neohesperidine dihydrochalcone as a sensory additive for fish (EFSA FEEDAP)Source →
- Scientific Opinion on the safety and efficacy of neohesperidine dihydrochalcone when used as a sensory additive for piglets, pigs for fattening, calves for rearing and fattening, lambs for rearing and fattening, dairy sheep, ewes for reproduction, salmonids and dogs (EFSA FEEDAP)Source →
- Flavouring Group Evaluation 32 (FGE.32): Flavonoids (Flavanones and dihydrochalcones) from chemical groups 25 and 30 (EFSA CEF)Source →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
GLOBALJECFATemporary ADI of 0–3.8 mg/kg bw per dayJECFA evaluation lists ADI Temporary ADI of 0–3.8 mg/kg bw per day. Functional class: sweetener.
- JECFA evaluation lists ADI Temporary ADI of 0–3.8 mg/kg bw per day. Functional class: sweetener.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 26 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Deodorizer, Flavouring and nutrient, Fragrance.
- EPA CPDat observed this chemical in 26 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Deodorizer, Flavouring and nutrient, Fragrance.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Scientific Opinion on the safety of neohesperidine dihydrochalcone as a sensory additive for fish (EFSA FEEDAP)
  2014 · EU EFSA listing · Read the source →
- Scientific Opinion on the safety and efficacy of neohesperidine dihydrochalcone when used as a sensory additive for piglets, pigs for fattening, calves for rearing and fattening, lambs for rearing and fattening, dairy sheep, ewes for reproduction, salmonids and dogs (EFSA FEEDAP)
  2011 · EU EFSA listing · Read the source →
- Flavouring Group Evaluation 32 (FGE.32): Flavonoids (Flavanones and dihydrochalcones) from chemical groups 25 and 30 (EFSA CEF)
  2010 · EU EFSA listing · Read the source →
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI Temporary ADI of 0–3.8 mg/kg bw per day. Functional class: sweetener.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Neohesperidin dihydrochalcone yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated September 2018
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Neohesperidin dihydrochalcone in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Personal care

Typical roles

FlavouringPerfumingFragranceSweetenerDeodorant

See products using Neohesperidin dihydrochalcone →

Catalog

Found in these products

Their ingredient lists include Neohesperidin dihydrochalcone; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 6 →Find products without it →