beauty
cleaning
industrial
pharma

Edetate sodium

CAS 7379-28-4

Also registered as 6 other CAS numbers

8013-51-2 · 8023-21-0 · 50809-35-3 · 70699-53-5 · 97928-93-3 · 64-02-8

Concern score

Not assessed — no hazard data yet.

Edetate sodium in plain language

What it is: On cosmetic ingredient lists it appears as “Tetrasodium EDTA”.
Also known as Tetrasodium EDTA · Sodium edetate · Tetrasodium edetate · Edetate · EDTA tetrasodium · EDTA tetrasodium salt
Show all 37 names
Ethylenediaminetetraacetic acid tetrasodium salt · Acetic acid, (ethylenedinitrilo)tetra-, sodium salt · EDTA sodium · Sodium EDTA · Versene 100 · (ethylenedinitrilo) tetraacetic acid tetrasodium salt · Aethylendiamin-tetraessigsaeure-tetra-na-salz · Acetic acid, (ethylenedinitrilo)tetra-, tetrasodium salt · Aquamoline BC · Aquamollin · Aquamollin BC · Calsol · Complexone · Celon E · Edetate tetrasodium · tetrasodium salt EDTA · Endrate tetrasodium · Ergon · Nervanaid · Nullapo · Na4EDTA · Nervanaid B · Nullapon B · Sodium ethylenediaminetetraacetate · Syntes 12A · Sequestrene · Trilon b · Tetrasodium ethylenediaminetetraacetate · Tetrine · Versene 220 · Versene powder
What it does: Used in cosmetics as a chelating agent.
Chelating
Preservative
Chelating agent
Thickener
Fragrance
Cleaning agent
Is it a concern?: We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Edetate sodium appears in these published regulatory listings.

Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Cleaning
Industrial

USFDAinactive ingredient database12 entries — 5 administration routes
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Potency: 0.01 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 0.01 %w/vSource →
- Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Potency: 0.04 %w/vSource →
- Route: OPHTHALMIC; Dosage form: EMULSION; Potency: 0.02 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 0.1 %w/vSource →
- Route: ORAL; Dosage form: CAPSULE; Potency: 1 mgSource →
- Route: ORAL; Dosage form: TABLET; Potency: 5 mgSource →
- Route: TOPICAL; Dosage form: LOTION; Potency: 0.17 %w/wSource →
- Route: TOPICAL; Dosage form: SHAMPOO; Potency: 1.33 %w/wSource →
- Route: TOPICAL; Dosage form: SOAP; Potency: 0.12 %w/wSource →
- Route: TOPICAL; Dosage form: SOLUTION; Potency: 0.3 %w/wSource →
- Route: TOPICAL; Dosage form: SPONGE; Potency: 0.14 %w/wSource →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 8553 composition records across product categories including Construction and building materials, Furniture and furnishings, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Chelating agent, Processing aids not otherwise specified, Fragrance.
- EPA CPDat observed this chemical in 8553 composition records across product categories including Construction and building materials, Furniture and furnishings, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Chelating agent, Processing aids not otherwise specified, Fragrance.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Edetate sodium. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Edetate sodium yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated september 8, 2015
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Edetate sodium in a product composition. These are source records, not Greenveil catalog products.

Source records

8,553

Named organisations

Construction and building materialsFurniture and furnishingsLaboratory suppliesSpecialty occupational productsCleaning products and household careVehicle

Typical roles

ChelatingPreservativeChelating agentThickenerFragranceCleaning agent

See products using Edetate sodium →

Catalog

Found in these products

Their ingredient lists include Edetate sodium; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 1000+ →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Edetate sodium in the catalog.