# SODIUM BISULFATE

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid3033983
Categories: beauty, cleaning, food, industrial, pharma
Functions: Buffering, Acid, pH adjuster, Antimicrobial
Identifier: DTXSID3033983

> SODIUM BISULFATE: Used in cosmetics as a pH buffer. Greenveil chemical-concern score: 40/100 — Moderate concern based on regulatory listings.. Compiled from 9 published data sources.

## Safety assessment

- Chemical concern score: 40/100 — Moderate concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 169 composition records across product categories including Specialty occupational products, Laboratory supplies, Personal care.

## Regulatory status

- EU: Active — Listed in CosIng inventory for cosmetic use.
- EU: EFSA opinion — Re-evaluation of sulphuric acid and its sodium, potassium, calcium and ammonium salts (E 513, 514 (i), 514 (ii), 515 (i), 515 (ii), 516 and 517) as food additive (EFSA FAF)
- EU: EFSA opinion — Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all animal species as preservative and silage additive, for pets and other non food-producing animals (non-food fur animals) as acidity regulator and for pets as flavouring (EFSA FEEDAP)
- EU: EFSA opinion — Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all species as preservative and silage additive (EFSA FEEDAP)
- GLOBAL: Evaluated — JECFA evaluation record. Functional class: acid.
- US: commercial use observed — EPA CPDat observed this chemical in 169 composition records across product categories including Specialty occupational products, Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Processing aids not otherwise specified, Biocide.
- US: inactive ingredient database — Route: RESPIRATORY (INHALATION); Dosage form: SOLUTION; Potency: 0.01 %w/w
- US: inactive ingredient database — Route: SUBCUTANEOUS; Dosage form: INJECTION; Potency: 0.1 %w/v
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.
- US: inactive ingredient database — Route: ORAL; Dosage form: CONCENTRATE; Potency: 0.95 mg/1ml
- US: inactive ingredient database — Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 0.32 %w/v
- US: inactive ingredient database — Route: INTRAMUSCULAR; Dosage form: INJECTION; Potency: 0.32 %w/v
- US: inactive ingredient database — Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Potency: 0.06 %w/v

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.
- EFSA (European Food Safety Authority): Re-evaluation of sulphuric acid and its sodium, potassium, calcium and ammonium salts (E 513, 514 (i), 514 (ii), 515 (i), 515 (ii), 516 and 517) as food additive (EFSA FAF) — 2019 — https://doi.org/10.2903/j.efsa.2019.5868; Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all animal species as preservative and silage additive, for pets and other non food-producing animals (non-food fur animals) as acidity regulator and for pets as flavouring (EFSA FEEDAP) — 2011 — https://doi.org/10.2903/j.efsa.2011.2415; Scientific Opinion on the safety and efficacy of sodium bisulphate (SBS) for all species as preservative and silage additive (EFSA FEEDAP) — 2014 — https://doi.org/10.2903/j.efsa.2014.3731.
- JECFA (Joint FAO/WHO Expert Committee on Food Additives): JECFA evaluation record. Functional class: acid. — https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/5692.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/37739
- EFSA OpenFoodTox (updated 2026-10-04): https://doi.org/10.5281/zenodo.8120114
- EPA Chemical and Products Database (updated September 2013): http://siri.org/msds/f2/byn/bynhn.html
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA Inactive Ingredient Database (updated 2026-01-09): https://www.fda.gov/drugs/drug-approvals-and-databases/inactive-ingredients-database-download
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- WHO JECFA Database (updated 2026-10-04): https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/5692
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:BU8V88OWIQ
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/516919

_Assessed by Greenveil._