# Interleukin-2

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid3040516
Categories: beauty, industrial
Functions: Skin conditioning, Conditioner
Identifier: DTXSID3040516

> Interleukin-2: Used in cosmetics as a skin-conditioning agent. EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. Compiled from 5 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.

## Regulatory status

- EU: Active — rh-Polypeptide-12 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Interleukin-4. It contains a maximum of 153 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids Restriction: II/416
- EU: Active — rh-Polypeptide-25 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Interleukin- 2. It contains a maximum of 153 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids Restriction: II/416
- EU: Active — rh-Polypeptide-6 is a single chain recombinant human peptide, produced by fermentation in E. coli. The starting gene is directly isolated from a human cell which codes for Interleukin-10. It contains a maximum of 178 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids Restriction: II/416
- US: commercial use observed — EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Softener and conditioner.
- US: commercial use observed — EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as protein.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/85178
- EPA Chemical and Products Database (updated 2019-12-31): https://ec.europa.eu/growth/tools-databases/cosing/index.cfm?fuseaction=search.details_v2&id=85184
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:72WT6YGC0U

_Assessed by Greenveil._