Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Methotrexate
EPA CPDat observed this chemical in 27 composition records across product categories including Food and drug.
Research docs0Claims0Sources6FunctionNo specific technical functionIdentifierDTXSID4020822
Concern score
5/100Low concern based on regulatory listings.
Well researched
How we scored this
The concern value reflects this ingredient's chemical identity — its hazard profile from the published classifications and regulatory status below — not the safety of a product it appears in. A score near 40 is the baseline for ingredients with no specific signal (water scores 40 by design), so a mid-range value is not a safety verdict.
Concern score 5/100 (low) · high confidence.
Where it appears
Prevalence of Methotrexate in our catalog (epa_cpdat).
Products
27
Brands
6
Food and drug
Typical roles
No specific technical function
Catalog
Found in these products
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Good fit
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
Linked research
Primary documents currently linked to this ingredient record.
No linked research documents are attached to this ingredient yet.
Extracted claims
Structured claim signals pulled from linked ingredient research.
No extracted claims are attached to this ingredient yet.
Regulatory status
Published jurisdiction-level classifications and regulatory designations for this ingredient.
US
EPA
EPA CPDat observed this chemical in 27 composition records across product categories including Food and drug. EPA CPDat classifies this chemical for functional uses including No specific technical function.
Effective: March 8, 2019View source →
US
FDA
FDA NDC lists this ingredient in 13 active drug products and 20 total products.
Effective: 2027-12-31View source →
US
FDA