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Urea

CAS 3138-51-0 · 40/100 · High conf.

Also registered as 14 other CAS numbers

4744-36-9 · 37955-36-5 · 30535-50-3 · 118548-06-4 · 860639-56-1 · 923953-70-2 · 1202865-46-0 · 1228376-38-2 · 1262769-89-0 · 1637232-71-3 · 2060607-07-8 · 2417243-36-6 · 2694035-40-8 · 57-13-6

Urea chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Urea in plain language

What it is

Also known as Azobisformamide · Carbamide · Azodicarboxylic acid-diamide · Alphadrate · Amide of carbonic acid · Aqua Care

Show all 38 names

Aquacare · Aquadrate · Basodexan · Carbaderm · Carbamide resin · Carbamimidic acid · Carbonyl diamide · Carbonyldiamide · Carbonyldiamine · E-927A · Elaqua XX · Harnstoff · Ins NO.927A · INS-927A · Keratinamin · Mocovina · Nutraplus · Pastaron · Ultra Mide · Urea Scavenger · Ureaphil · Ureophil · Urepearl · Urevert · Varioform ii · urea (sulfur coated) · urea (urethane preolymer) · ureum · Alphaderm component urea · Calmurid hc component urea · Carmol hc component urea · U-cort component urea

What it does

Used in cosmetics as a humectant, a skin-conditioning agent and an antistatic agent.

  • Humectant
  • Skin conditioning
  • Antistatic
  • Buffering
  • Texturizer, thickener, yeast food, chewing gum base compound
  • pH adjuster
Is it a concern?
Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 1595 composition records across product categories including Construction and building materials, Furniture and furnishings, Tools.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Urea appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Food
  • Industrial
  • USFDAinactive ingredient database7 entries — 3 administration routes
    • Route: VAGINAL; Dosage form: CREAM; Potency: 0.64 %w/wSource →
    • Route: VAGINAL; Dosage form: DOUCHE; Potency: 8 %w/wSource →
    • Route: VAGINAL; Dosage form: INSERT; Maximum daily exposure: 50 mgSource →
    • Route: ORAL; Dosage form: TABLET, EFFERVESCENT; Potency: 60 mgSource →
    • Route: ORAL; Dosage form: TABLET, COATED; Potency: 0.02 mgSource →
    • Route: TOPICAL; Dosage form: SYSTEM; Maximum daily exposure: 840 mgSource →
    • Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Potency: 0.01 mgSource →
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • EUEFSAEFSA opinionScientific Opinion on the safety and efficacy of Urea for ruminants (EFSA FEEDAP)
    • Scientific Opinion on the safety and efficacy of Urea for ruminants (EFSA FEEDAP)Source →
  • EUEFSAConclusion on Pesticides Peer ReviewConclusion on the peer review of the pesticide risk assessment of the active substance urea (EFSA)
    • Conclusion on the peer review of the pesticide risk assessment of the active substance urea (EFSA)Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record.
  • GLOBALJECFANOT SPECIFIEDJECFA evaluation lists ADI NOT SPECIFIED. Functional class: texturizer, thickener, yeast food, chewing gum base compound.
    • JECFA evaluation lists ADI NOT SPECIFIED. Functional class: texturizer, thickener, yeast food, chewing gum base compound.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 1595 composition records across product categories including Construction and building materials, Furniture and furnishings, Tools. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Humectant, Anti-static agent.
    • EPA CPDat observed this chemical in 1595 composition records across product categories including Construction and building materials, Furniture and furnishings, Tools. EPA CPDat classifies this chemical for functional uses including pH regulating agent, Humectant, Anti-static agent.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 40 active drug products and 40 total products.
    • FDA NDC lists this ingredient in 40 active drug products and 40 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Scientific Opinion on the safety and efficacy of Urea for ruminants (EFSA FEEDAP)

      2012 · EU EFSA listing · Read the source →

    • Conclusion on the peer review of the pesticide risk assessment of the active substance urea (EFSA)

      2012 · EU EFSA listing · Read the source →

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation record.

      Year not recorded · GLOBAL JECFA listing · Read the source →

    • JECFA evaluation lists ADI NOT SPECIFIED. Functional class: texturizer, thickener, yeast food, chewing gum base compound.

      Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Urea yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

10 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated october 25, 2016

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

codexalimentarius.net

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Urea in a product composition. These are source records, not Greenveil catalog products.

Source records

1,595

Named organisations

6

Construction and building materialsFurniture and furnishingsToolsLaboratory suppliesLandscape/yardPackaging (non-food contact)

Typical roles

HumectantSkin conditioningAntistaticBufferingTexturizer, thickener, yeast food, chewing gum base compoundpH adjuster
See products using Urea →

Catalog

Found in these products

Their ingredient lists include Urea; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 355 →Find products without it →