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Propylparaben

CAS 94-13-3 · 40/100 · High conf.

Also registered as 3 other CAS numbers

85403-59-4 · 58339-85-8 · 59593-07-6

Propylparaben chemical structure

Concern score

40/100Moderate concern based on regulatory listings.
High confidence

Propylparaben in plain language

What it is

Also known as Propyl hydroxybenzoate · Propyl parahydroxybenzoate · Propyl p-hydroxybenzoate · Propyl paraben · Benzoic acid, 4-HYDROXY-, propyl ester · Propyl para-hydroxybenzoate

Show all 34 names

Propylparaben E216 · Propyl 4-hydroxybenzoate · Tegosept p · 4-HYDROXYBENZOESAEURE-PROPYLESTER · 4-HYDROXYBENZOIC acid propylester · 4-Hydroxybenzoate de propyle · 4-Hydroxybenzoic acid propyl ester · 4-hidroxibenzoato de propilo · Aseptoform P · Betacide P · Chemocide pk · Nipagin p · Nipasol · Nipazol · Nipasol P · Paraben p · Paratexin p · Propagin · Paseptol · Propyl Butex · Propyl Chemosept · Propyl Parasept · Propylparasept · Solbrol P · aseptoform propyl · n-Propyl 4-hydroxybenzoate · propyl 4-hydroxybenzoate (propyl parabens) · propyl paraben - 2 mg/vial

What it does

Used in food as a preservative.

  • Preservative
  • Fragrance
  • Flavouring
  • Conditioner
  • Antimicrobial
Is it a concern?
Moderate concern: no hazard classifications on record.

Why it's flagged

EPA CPDat observed this chemical in 11696 composition records across product categories including Home maintenance, Personal care, Pesticides.

RestrictedGLOBAL JECFA — WITHDRAWN (2006)

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

Restrictions first, then routine listings from published regulatory sources.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Pharma
  • Food
  • Industrial

  • GLOBALJECFA

    JECFA evaluation lists ADI WITHDRAWN (2006). Functional class: preservative.

    WITHDRAWN (2006)
    View source →
  • USFDAinactive ingredient database69 entries — 18 administration routes
    • Route: BUCCAL; Dosage form: FILM, SOLUBLE; Maximum daily exposure: 1 mgSource →
    • Route: DENTAL; Dosage form: PASTE, DENTIFRICE; Potency: NASource →
    • Route: INFILTRATION; Dosage form: INJECTION; Potency: 0.35 mgSource →
    • Route: INTRA-ARTICULAR; Dosage form: INJECTION; Potency: 0.03 %w/vSource →
    • Route: INTRALESIONAL; Dosage form: INJECTION; Potency: 0.02 %w/vSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 6 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: 0.4 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 5 mgSource →
    • Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION; Potency: 0.02 %w/vSource →
    • Route: INTRAMUSCULAR; Dosage form: SOLUTION; Potency: 0.02 %w/vSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 6 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, POWDER, FOR SOLUTION; Potency: 0.8 mgSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 5 mgSource →
    • Route: INTRAVENOUS; Dosage form: SOLUTION; Potency: 0.02 %w/vSource →
    • Route: NASAL; Dosage form: DROPS; Potency: 14 mgSource →
    • Route: NASAL; Dosage form: JELLY; Potency: 140 mgSource →
    • Route: NASAL; Dosage form: SOLUTION; Potency: 140 mgSource →
    • Route: NASAL; Dosage form: SPRAY; Potency: 0.2 mgSource →
    • Route: OPHTHALMIC; Dosage form: DROPS; Potency: 0.01 %w/wSource →
    • Route: OPHTHALMIC; Dosage form: OINTMENT; Potency: 0.01 %w/wSource →
    • Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 0.02 %w/wSource →
    • Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Potency: 0.01 %w/vSource →
    • Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Potency: 0.01 %w/wSource →
    • Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 1 mgSource →
    • Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Potency: 0.22 mgSource →
    • Route: ORAL; Dosage form: CONCENTRATE; Potency: 2.5 mg/5mlSource →
    • Route: ORAL; Dosage form: ELIXIR; Potency: 200 mgSource →
    • Route: ORAL; Dosage form: LIQUID; Maximum daily exposure: 2 mgSource →
    • Route: ORAL; Dosage form: POWDER; Potency: NASource →
    • Route: ORAL; Dosage form: POWDER, FOR SOLUTION; Maximum daily exposure: 13 mgSource →
    • Route: ORAL; Dosage form: POWDER, FOR SUSPENSION; Maximum daily exposure: 8 mgSource →
    • Route: ORAL; Dosage form: SOLUTION; Potency: 100 mgSource →
    • Route: ORAL; Dosage form: SOLUTION, CONCENTRATE; Potency: 0.2 mg/1mlSource →
    • Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 64 mgSource →
    • Route: ORAL; Dosage form: SUSPENSION, EXTENDED RELEASE; Maximum daily exposure: 4 mgSource →
    • Route: ORAL; Dosage form: SYRUP; Maximum daily exposure: 40 mgSource →
    • Route: ORAL; Dosage form: TABLET; Potency: 0.2 mgSource →
    • Route: ORAL; Dosage form: TABLET, CHEWABLE; Potency: 0.14 mgSource →
    • Route: ORAL; Dosage form: TABLET, COATED; Potency: 0.8 mgSource →
    • Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Potency: 0.12 mgSource →
    • + 29 more entries not shown
  • EUEFSAEFSA opinionOpinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) (EFSA AFC)
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) (EFSA AFC)Source →
  • GLOBALJECFAEvaluatedJECFA evaluation record.
  • USEPAcommercial use observedEPA CPDat observed this chemical in 11696 composition records across product categories including Home maintenance, Personal care, Pesticides. EPA CPDat classifies this chemical for functional uses including Preservative, Fragrance, Food preservative.
    • EPA CPDat observed this chemical in 11696 composition records across product categories including Home maintenance, Personal care, Pesticides. EPA CPDat classifies this chemical for functional uses including Preservative, Fragrance, Food preservative.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 4 active drug products and 12 total products.
    • FDA NDC lists this ingredient in 4 active drug products and 12 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • JECFA

    Joint FAO/WHO Expert Committee on Food Additives

    • JECFA evaluation lists ADI WITHDRAWN (2006). Functional class: preservative.

      Year not recorded · GLOBAL JECFA listing · Read the source →

    • JECFA evaluation record.

      Year not recorded · GLOBAL JECFA listing · Read the source →

  • EFSA

    European Food Safety Authority

    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on a Request from the Commission related to para hydroxybenzoates (E 214-219) (EFSA AFC)

      2004 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Propylparaben yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated september 28, 2015

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2029-06-12

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • WHO JECFA Database

    regulatory · updated 2026-10-04

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →
Reference links (1)
Openfda substance

en.wikipedia.org

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed Propylparaben in a product composition. These are source records, not Greenveil catalog products.

Source records

11,696

Named organisations

6

Home maintenancePersonal carePesticidesLaboratory suppliesFood and drugRaw materials

Typical roles

PreservativeFragranceFlavouringConditionerAntimicrobial
See products using Propylparaben →

Catalog

Found in these products

Their ingredient lists include Propylparaben; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 579 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Propylparaben in the catalog.