- beauty
- industrial
- pharma
13-cis Retinoic acid
CAS 4759-48-2
Concern score
Not assessed — no hazard data yet.
13-cis Retinoic acid in plain language
On cosmetic ingredient lists it appears as “Cis-retinoic acid”.
Also known as Cis-retinoic acid · Isotretinoin · Retinoic acid 13-CIS-FORM · (13cis)-Retinoic acid · 13-CIS-RETINOIC acid · Retinoic acid, 13-CIS-
Show all 31 names
Vitamin a acid, 13-CIS · (13Z)-Retinoic acid · 13-RA · 13-cis-Vitamin A acid · 13-cis-beta-Retinoic acid · 13-cis-β-Retinoic acid · Absorica · Absorica ld · Accutane · Amnesteem · Claravis · Isotretinoine · Isotretinoinum · Isotrex · Neovitamin A acid · PAT-001 · Ro 4-3780 · RO-43780 · Roaccutan · Roaccutane · Roacutan · Sotret · Teriosal · isotretinoina · isotretinoino
Used in cosmetics as an anti-sebum.
- Anti-sebum
- We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
Regulation
No restrictions found. 13-cis Retinoic acid appears in these published regulatory listings.
- In marketed US drugs
- Found in consumer products
- Industrial
EUCosIngActivecis-Retinoic Acid is the organic compound that conforms to the formula Restriction: II/375
- cis-Retinoic Acid is the organic compound that conforms to the formula Restriction: II/375Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
- EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 94 active drug products and 94 total products.
- FDA NDC lists this ingredient in 94 active drug products and 94 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
No expert opinion on file for 13-cis Retinoic acid. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for 13-cis Retinoic acid yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EPA Chemical and Products Database
exposure · updated March 8, 2019
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Where it has been recorded
How often FDA National Drug Code directory has listed 13-cis Retinoic acid in a product composition. These are source records, not Greenveil catalog products.
Source records
94
Typical roles
Anti-sebum