- cleaning
- food
- industrial
- pharma
Polyethylene glycol 400
CAS 25322-68-3 · 40/100 · High conf.
Also registered as 123 other CAS numbers
8038-37-7 · 9081-95-2 · 9085-02-3 · 9085-03-4 · 12676-74-3 · 12770-93-3 · 25104-58-9 · 25609-81-8 · 34802-42-1 · 37361-15-2 · 50809-04-6 · 50809-59-1 · 51312-32-4 · 54510-95-1 · 54847-64-2 · 59763-40-5 · 60894-12-4 · 61840-14-0 · 64441-68-5 · 64640-28-4 · 67411-64-7 · 70926-57-7 · 75285-02-8 · 75285-03-9 · 77986-38-0 · 79964-26-4 · 80341-53-3 · 85399-22-0 · 85945-29-5 · 88077-80-9 · 88747-22-2 · 90597-70-9 · 99264-61-6 · 99333-89-8 · 101677-86-5 · 106186-24-7 · 107502-63-6 · 107529-96-4 · 109550-27-8 · 112384-37-9 · +83 more
Concern score
40/100Moderate concern based on regulatory listings.
High confidence
Polyethylene glycol 400 in plain language
Also known as Polyethylene glycol 3350 · Polyethylene glycol 1000 · Polyethylene glycol 4000 · Polyethylene glycol 6000 · Polyethylene glycol 8000 · Polyethylene glycol 20000
Show all 294 names
Macrogol · Macrogol 1500 · Macrogol 4000 · Polyethylene glycol · PEG-100 · PEG-14M · PEG-200 · PEG-75 · PEG-90M · Polyethylene glycol 1450 · Polyethylene glycol 1500 · Polyethylene glycol 3000 · Polyethylene glycol 3500 · Polyethylene glycol 4500 · Polyethylene glycol 7000 · Polyethylene glycol 7000000 · Polyethylene glycol 900 · Macrogol 1000 · Macrogol 20000 · Macrogol 3350 · Macrogol 6000 · Macrogols · PEG-3350 · Polyethylene glycol 1540 · Polyethylene glycol 200000 · Polyethylene glycol 75 · Polyethylene glycols · Polyethylene oxide · Polyoxyethylene · PEG · Polyethylene glycol 10000 · Polyethylene glycol 11000 · Polyethylene glycol 12000 · Polyethylene glycol 14000 · Polyethylene glycol 1600 · Polyethylene glycol 2000 · Polyethylene glycol 35000 · Polyethylene glycol 5000 · Polyethylene glycol 9000 · Unspecified polyethylene glycol · Polyethylene oxide 100000 · Polyethylene oxide 1000000 · Polyethylene oxide 200000 · Polyethylene oxide 2000000 · Polyethylene oxide 300000 · Polyethylene oxide 400000 · Polyethylene oxide 4000000 · Polyethylene oxide 5000000 · Polyethylene oxide 600000 · Polyethylene oxide 7000000 · Polyethylene oxide 8000000 · Polyethylene oxide 900000 · Golytely · PEG-115M · PEG-135 · PEG-150 · PEG-160M · PEG-18 · PEG-180 · PEG-180M · PEG-20 · PEG-20M · PEG-220 · PEG-23M · PEG-240 · PEG-2M · PEG-32 · PEG-33 · PEG-40 · PEG-45 · PEG-450 · PEG-45M · PEG-5M · PEG-60 · PEG-7M · PEG-80 · PEG-800 · PEG-90 · PEG-9M · Polyethylene glycol 100000 · Polyethylene glycol 1000000 · Polyethylene glycol 200 · Polyethylene glycol 2000000 · Polyethylene glycol 300-1600 · Polyethylene glycol 300000 · Polyethylene glycol 400000 · Polyethylene glycol 4000000 · Polyethylene glycol 600000 · Polyethylene glycol 800 · Polyethylene glycol 8000000 · Polyethylene glycol 900000 · Polyethylene oxides · Alkox L-11 · Carbowax 1000 · Carbowax 1540 · Carbowax 4000 · Carbowax 6000 · Carbowax 8000 · Carbowax PEG 3350 · Carbowax PEG 8000 · Macrogol 10000 · Macrogol 1000000 · Macrogol 11000 · Macrogol 12000 · Macrogol 14000 · Macrogol 1450 · Macrogol 2000 · Macrogol 200000 · Macrogol 2000000 · Macrogol 3000 · Macrogol 300000 · Macrogol 3500 · Macrogol 35000 · Macrogol 400000 · Macrogol 4000000 · Macrogol 4500 · Macrogol 5000 · Macrogol 5000000 · Macrogol 600000 · Macrogol 7000 · +168 more
Used in food as an adjuvant, carrier solvent.
- Adjuvant, carrier solvent
- Emulsifier
- Surfactant
- Humectant
- Thickener
- Solvent
- Moderate concern: no hazard classifications on record.
Why it's flagged
EPA CPDat observed this chemical in 1279 composition records across product categories including Construction and building materials, Furniture and furnishings, Construction.
The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.
Regulation
No restrictions found. Polyethylene glycol 400 appears in these published regulatory listings.
- In marketed US drugs
- Inactive ingredient in US drugs
- Found in consumer products
- Cleaning
- Pharma
- Industrial
USFDAinactive ingredient database168 entries — 19 administration routes
- Route: ORAL; Dosage form: TABLET, FILM COATED; Potency: 1.52 mgSource →
- Route: RECTAL; Dosage form: SUPPOSITORY; Potency: 1658 mgSource →
- Route: TOPICAL; Dosage form: AEROSOL, FOAM; Potency: NASource →
- Route: TOPICAL; Dosage form: CREAM; Potency: 0.5 %w/wSource →
- Route: TOPICAL; Dosage form: GEL; Maximum daily exposure: 50 mgSource →
- Route: TRANSDERMAL; Dosage form: GEL; Potency: 0.5 %w/wSource →
- Route: VAGINAL; Dosage form: SUPPOSITORY; Potency: NASource →
- Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Maximum daily exposure: 91 mgSource →
- Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 6108 mgSource →
- Route: ORAL; Dosage form: SUSPENSION; Maximum daily exposure: 4000 mgSource →
- Route: ORAL; Dosage form: TABLET; Potency: 0.6 mgSource →
- Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Maximum daily exposure: 9 mgSource →
- Route: ORAL; Dosage form: TABLET, FILM COATED; Potency: 0.13 mgSource →
- Route: TOPICAL; Dosage form: OINTMENT; Maximum daily exposure: 921 mgSource →
- Route: URETHRAL; Dosage form: SUPPOSITORY; Potency: 9.75 mgSource →
- Route: DENTAL; Dosage form: GEL; Potency: 5 %w/wSource →
- Route: DENTAL; Dosage form: PASTE; Potency: 4.96 %w/wSource →
- Route: ORAL; Dosage form: TABLET; Potency: 1.2 mgSource →
- Route: ORAL; Dosage form: TABLET, COATED; Potency: NASource →
- Route: RECTAL; Dosage form: SUPPOSITORY; Potency: 0.3 mg/mgSource →
- Route: TOPICAL; Dosage form: SOLUTION; Potency: 29.7 %w/wSource →
- Route: AURICULAR (OTIC); Dosage form: DROPS; Potency: 9.98 %w/wSource →
- Route: ORAL; Dosage form: CAPSULE; Potency: NASource →
- Route: ORAL; Dosage form: SOLUTION; Maximum daily exposure: 1440 mgSource →
- Route: TOPICAL; Dosage form: OINTMENT; Potency: 39 %w/wSource →
- Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 108 mgSource →
- Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 17 mgSource →
- Route: ORAL; Dosage form: TABLET, DELAYED RELEASE; Potency: 0.01 mgSource →
- Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 1 mgSource →
- Route: INTRA-ARTICULAR; Dosage form: INJECTION; Maximum daily exposure: 56 mgSource →
- Route: INTRA-ARTICULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 56 mgSource →
- Route: INTRALESIONAL; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 87 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION; Maximum daily exposure: 56 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 87 mgSource →
- Route: INTRAMUSCULAR; Dosage form: INJECTION, SUSPENSION, EXTENDED RELEASE; Maximum daily exposure: 60 mgSource →
- Route: INTRASYNOVIAL; Dosage form: INJECTION; Potency: 3 %w/vSource →
- Route: INTRASYNOVIAL; Dosage form: INJECTION, SUSPENSION; Maximum daily exposure: 87 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 0.5 mlSource →
- Route: NASAL; Dosage form: SPRAY, METERED; Maximum daily exposure: 96 mgSource →
- Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 576 mgSource →
- + 128 more entries not shown
USFDAmarketed drug occurrence3 entries
GLOBALJECFAEvaluatedJECFA evaluation record.
- JECFA evaluation record.Source →
GLOBALJECFA0-10 mg/kg bwJECFA evaluation lists ADI 0-10 mg/kg bw. Functional class: adjuvant, carrier solvent.
- JECFA evaluation lists ADI 0-10 mg/kg bw. Functional class: adjuvant, carrier solvent.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 1279 composition records across product categories including Construction and building materials, Furniture and furnishings, Construction. EPA CPDat classifies this chemical for functional uses including Solvent, Binder, Processing aids not otherwise specified.
- EPA CPDat observed this chemical in 1279 composition records across product categories including Construction and building materials, Furniture and furnishings, Construction. EPA CPDat classifies this chemical for functional uses including Solvent, Binder, Processing aids not otherwise specified.Source →
Expert safety opinions
Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
JECFA evaluation record.
Year not recorded · GLOBAL JECFA listing · Read the source →
JECFA evaluation lists ADI 0-10 mg/kg bw. Functional class: adjuvant, carrier solvent.
Year not recorded · GLOBAL JECFA listing · Read the source →
EFSA
European Food Safety Authority
No EFSA opinion on file.
Evidence & sources
No graded research studies for Polyethylene glycol 400 yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
EPA Chemical and Products Database
exposure · updated september 10, 2014
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
- Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
WHO JECFA Database
regulatory · updated 2026-10-04
- Open →
openFDA Substance
registry · updated 2026-05-24
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Food-use source coverage is present in the current record.
The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.
Fragrance avoidance
No fragrance-linked caution surfaced in the current profile.
This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.
Where it has been recorded
How often EPA CPDat has listed Polyethylene glycol 400 in a product composition. These are source records, not Greenveil catalog products.
Source records
1,279
Named organisations
6
Construction and building materialsFurniture and furnishingsConstructionHome maintenanceCleaning and safetySpecialty occupational products
Typical roles
Adjuvant, carrier solventEmulsifierSurfactantHumectantThickenerSolvent
Found in these products
Their ingredient lists include Polyethylene glycol 400; each product's own rating depends on its whole formula, so it is shown on the product page, not here.
- pantine pro-vpantine · Open Beauty Facts
- Bicarbonato BlanqueadorDeliplus
- Curling creamCantu
- Signal Integral 8 Dentifrice Nature Elements Bicarbonate 75mlUnilever, Signal, Integral 8 · Hygiene
- AntheliosLa Roche-Posay · Suncare
- Pampers fresh cleanPampers · Non Open Products Facts
- Signal Dentifrice Anti-Tartre 75mlunilever, signal · Non Food Products
- Jordan Junior 6-12 Jaar TandpastaKindertandpasta
- Mascarilla sin aclarado Argan OilDeliplus · Open Beauty Facts
- Dentífrico infantil +6 añosDeliplus
- Mixa 50+ lait fondant solaireMixa · Laits Solaires
- Gel douche Total Clean 5 en 1 (format XL)L'Oréal, L'Oreal Consumer products, L'Oréal Paris, L'Oréal Men Expert · Hygiene
- Dentífrico 3 actionDeliplus · Cosmetic Products
- Dentífrico infantil + 2 añosDeliplus · Non Food Products
- studio line remixL'Oréal, L'Oreal Consumer products · Hair
- Dentífrico infantil +6 añosDeliplus
- Williams Mousse à Raser Homme Peau Sensible 200mlWilliams · Non Food Products
- Sig tp wn gold 75mlUnilever, Signal · Non Food Products
- Intensive Repair ShampooUnilever, Dove · Non Food Products
- dermo protecteurBy u
- Signal Dentifrice Expert Protection Haleine PureUnilever, Signal · Hygiene
- TOOTH PASTECHARCOAL · Open Beauty Facts
- Vitamin cNatural
- Effaclar DUO (+) SPF 30La Roche-Posay
Often appears with
Ingredients that frequently appear alongside Polyethylene glycol 400 in the catalog.