# PHENYLALANINE

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid4040763
Categories: beauty, food, industrial, pharma
Functions: Skin conditioning, Hair conditioning, Fragrance, Flavouring agent, Flavouring
Identifier: DTXSID4040763

> PHENYLALANINE: Used in cosmetics as a skin-conditioning agent, a hair conditioner and a fragrance ingredient. Greenveil chemical-concern score: 60/100 — High concern based on regulatory listings.. Compiled from 11 published data sources.

## Safety assessment

- Chemical concern score: 60/100 — High concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? High concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 3 composition records across product categories including Medical/dental, Laboratory supplies.

## Regulatory status

- EU: Active — Listed in CosIng inventory for cosmetic use.
- EU: EFSA opinion — Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP)
- EU: EFSA opinion — Flavouring Group Evaluation 79, (FGE.79). Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008). Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC)
- GLOBAL: No safety concern at current levels of intake when used as a flavouring agent — JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent.
- US: commercial use observed — EPA CPDat observed this chemical in 3 composition records across product categories including Medical/dental, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Flavouring and nutrient.
- US: marketed drug occurrence — FDA NDC lists this ingredient in 67 active drug products and 68 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.
- US: inactive ingredient database — Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Potency: 0.17 %w/v
- US: inactive ingredient database — Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 7.26 mg
- US: observed in branded food ingredient statements — Observed in 1 USDA branded foods including 1 LITER BOTTLE DIET BLACK CHERRY.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.
- EFSA (European Food Safety Authority): Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP) — 2014 — https://doi.org/10.2903/j.efsa.2014.3670; Flavouring Group Evaluation 79, (FGE.79). Consideration of amino acids and related substances evaluated by JECFA (63rd meeting) structurally related to amino acids from chemical group 34 evaluated by EFSA in FGE.26Rev1 (2008). Scientific Opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food (EFSA AFC) — 2008 — https://doi.org/10.2903/j.efsa.2008.870.
- JECFA (Joint FAO/WHO Expert Committee on Food Additives): JECFA evaluation lists ADI No safety concern at current levels of intake when used as a flavouring agent. Functional class: flavouring agent. — https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3942.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/79702
- EFSA OpenFoodTox (updated 2026-10-04): https://doi.org/10.5281/zenodo.8120114
- EPA Chemical and Products Database (updated February 8, 2019): http://siri.org/msds/f2/bkf/bkfbw.html
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA Inactive Ingredient Database (updated 2026-01-09): https://www.fda.gov/drugs/drug-approvals-and-databases/inactive-ingredients-database-download
- FDA National Drug Code Directory (updated 2027-12-31): https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory-support-files
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- WHO JECFA Database (updated 2026-10-04): https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/3942
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:47E5O17Y3R
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/6140
- USDA Branded Foods (updated 2026-02-19): https://fdc.nal.usda.gov/fdc-app.html#/food-details/2752435/details

_Assessed by Greenveil._