- beauty
- industrial
- pharma
Apaflurane
CAS 431-89-0
Concern score
Not assessed — no hazard data yet.
Apaflurane in plain language
On cosmetic ingredient lists it appears as “Hydrofluorocarbon 227EA”.
Also known as Hydrofluorocarbon 227EA · 1,1,1,2,3,3,3-Heptafluoropropane · 2H-Perfluoropropane · 2-HYDROHEPTAFLUOROPROPANE · 1,1,1,2,3,3,3-Heptafluoro-n-propane · 1,1,1,2,3,3,3-Heptafluorpropan
Show all 20 names
1,1,1,2,3,3,3-heptafluoropropano · 2-Hydroperfluoropropane · 2H-Heptafluoropropane · Apaflurano · Fm 200 · HFA-227 · HFA-227EA · HFC-227 · HFC-227EA · Khladon 227 · Propane, 1,1,1,2,3,3,3-heptafluoro- · R-227 · Solkane 227 · apafluranum
Used in cosmetics as a propellant.
- Propellant
- We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
Regulation
No restrictions found. Apaflurane appears in these published regulatory listings.
- Inactive ingredient in US drugs
- Found in consumer products
- Beauty
- Industrial
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 5 composition records across product categories including Personal care, Specialty occupational products, Industrial products. EPA CPDat classifies this chemical for functional uses including Propellants, non-motive (blowing agents), Pharmaceutical, Fire extinguishing agent.
- EPA CPDat observed this chemical in 5 composition records across product categories including Personal care, Specialty occupational products, Industrial products. EPA CPDat classifies this chemical for functional uses including Propellants, non-motive (blowing agents), Pharmaceutical, Fire extinguishing agent.Source →
USFDAinactive ingredient databaseRoute: RESPIRATORY (INHALATION); Dosage form: AEROSOL, METERED; Potency: 98.02 %w/w
- Route: RESPIRATORY (INHALATION); Dosage form: AEROSOL, METERED; Potency: 98.02 %w/wSource →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
No expert opinion on file for Apaflurane. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for Apaflurane yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EPA Chemical and Products Database
exposure · updated January 7, 2008
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Reference links (2)
en.wikipedia.org
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Where it has been recorded
How often EPA CPDat has listed Apaflurane in a product composition. These are source records, not Greenveil catalog products.
Source records
5
Named organisations
3
Personal careSpecialty occupational productsIndustrial products
Typical roles
Propellant