- beauty
- food
- industrial
- pharma
Tromethamine hydrochloride
CAS 10527-44-3
Also registered as 4 other CAS numbers
35087-75-3 · 150551-82-9 · 2650582-32-2 · 1185-53-1
Concern score
Not assessed — no hazard data yet.
Tromethamine hydrochloride in plain language
On cosmetic ingredient lists it appears as “Tromethamine hcl”.
Also known as Tromethamine hcl · Trometamol hydrochloride · 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydrochloride · Tris hydrochloride · Tris-hcl · Trizma hydrochloride
Show all 21 names
1,3-Propanediol, 2-amino-2-(hydroxymethyl)-, hydrochloride · 2-Amino-2-(hydroxymethyl)-1,3-propanediol hydrochloride · 2-Amino-2-(hydroxymethyl)propan-1,3-diolhydrochlorid · 2-Amino-2-(hydroxymethyl)propane-1,3-diol, chlorhydrate · 2-amino-2-(hidroximetil)propano-1,3-diol, clorhidrato · 2-amino-2-(hydroxymethyl)propane-1,3-diol hydrochloride · 2Amino2(hydroxymethyl)propane1,3diol hydrochloride · 2Amino2hydroxymethyl1,3propanediol hydrochloride · TRIS HCl · Tris(hydroxymethyl)aminomethane hydrochloride · Tris chloride · Tris hydrochloride buffer · UNII-383V75M34E · tris hydroxymethyl aminomethane (acid) · tris hydroxymethyl aminomethane (base)
Used in cosmetics as an antimicrobial. Tromethamine HCl is the amine salt.
- Antimicrobial
- We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
Regulation
No restrictions found. Tromethamine hydrochloride appears in these published regulatory listings.
- Found in consumer products
- Pharma
- Food
- Industrial
EUCosIngActiveTromethamine HCl is the amine salt that conforms to the formula:
- Tromethamine HCl is the amine salt that conforms to the formula:Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 78 composition records across product categories including Laboratory supplies, Food and drug, Raw materials.
- EPA CPDat observed this chemical in 78 composition records across product categories including Laboratory supplies, Food and drug, Raw materials.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
No expert opinion on file for Tromethamine hydrochloride. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
Evidence & sources
No graded research studies for Tromethamine hydrochloride yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
CosIng
regulatory · updated 2026-09-23
- Open →
EPA Chemical and Products Database
exposure · updated 2019-02-27
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Reference links (1)
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Where it has been recorded
How often EPA CPDat has listed Tromethamine hydrochloride in a product composition. These are source records, not Greenveil catalog products.
Source records
78
Laboratory suppliesFood and drugRaw materials
Typical roles
Antimicrobial