# Tromethamine hydrochloride

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid4044373
Categories: beauty, food, industrial, pharma
Functions: Antimicrobial
Identifier: DTXSID4044373

> Tromethamine hydrochloride: Used in cosmetics as an antimicrobial. Tromethamine HCl is the amine salt. EPA CPDat observed this chemical in 78 composition records across product categories including Laboratory supplies, Food and drug, Raw materials. Compiled from 6 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 78 composition records across product categories including Laboratory supplies, Food and drug, Raw materials.

## Regulatory status

- EU: Active — Tromethamine HCl is the amine salt that conforms to the formula:
- US: commercial use observed — EPA CPDat observed this chemical in 78 composition records across product categories including Laboratory supplies, Food and drug, Raw materials.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/98076
- EPA Chemical and Products Database (updated 2019-02-27): http://siri.org/msds/f2/cch/cchbc.html
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:383V75M34E
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/93573

_Assessed by Greenveil._