# VALINE

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid40883233
Categories: beauty, food, industrial, pharma
Functions: Skin conditioning, Hair conditioning, Antistatic, Fragrance, Flavouring
Identifier: DTXSID40883233

> VALINE: Used in cosmetics as a skin-conditioning agent, a hair conditioner and an antistatic agent. Greenveil chemical-concern score: 60/100 — High concern based on regulatory listings.. Compiled from 9 published data sources.

## Safety assessment

- Chemical concern score: 60/100 — High concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? High concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 1 composition records across product categories including unclassified products.

## Regulatory status

- EU: Active — Listed in CosIng inventory for cosmetic use.
- EU: EFSA opinion — Efficacy and safety of L-valine from a modified E.coli K12 for all animal species (EFSA FEEDAP, EFSA GMO)
- EU: EFSA opinion — Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP)
- EU: EFSA opinion — Scientific Opinion on Flavouring Group Evaluation 401 (FGE.401): gamma-Glutamyl-valyl-glycine from chemical group 34 (EFSA CEF)
- EU: EFSA opinion — Scientific Opinion on the safety and efficacy of L-valine produced by Corynebacterium glutamicum (KCCM 80058) for all animal species (EFSA FEEDAP)
- EU: EFSA opinion — Safety of L-valine for all animal species (EFSA FEEDAP)
- EU: EFSA opinion — Amino acids from chemical group 34. Flavouring Group Evaluation 26, Revision 1. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (EFSA AFC)
- EU: EFSA opinion — Scientific Opinion on the safety and efficacy of L-valine (L-valine, feed grade) produced by Escherichia coli NITE BP-01755 for all animal species based on a dossier submitted by Ajinomoto Eurolysine S.A.S (EFSA FEEDAP)
- EU: EFSA opinion — Scientific Opinion on the safety and efficacy of L-valine (ValAMINO) produced by Corynebacterium glutamicum (DSM 25202) for all animal species, based on a dossier submitted by Evonik Industries AG (EFSA FEEDAP)
- US: commercial use observed — EPA CPDat observed this chemical in 1 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including No specific technical function, Flavouring and nutrient, Fragrance.
- US: inactive ingredient database — Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 0.84 %w/v
- US: inactive ingredient database — Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Potency: 0.2 %w/v
- US: marketed drug occurrence — FDA NDC lists this ingredient in 67 active drug products and 68 total products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.
- EFSA (European Food Safety Authority): Efficacy and safety of L-valine from a modified E.coli K12 for all animal species (EFSA FEEDAP, EFSA GMO) — 2008 — https://doi.org/10.2903/j.efsa.2008.695; Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP) — 2014 — https://doi.org/10.2903/j.efsa.2014.3670; Scientific Opinion on Flavouring Group Evaluation 401 (FGE.401): gamma-Glutamyl-valyl-glycine from chemical group 34 (EFSA CEF) — 2014 — https://doi.org/10.2903/j.efsa.2014.3625; Scientific Opinion on the safety and efficacy of L-valine produced by Corynebacterium glutamicum (KCCM 80058) for all animal species (EFSA FEEDAP) — 2013 — https://doi.org/10.2903/j.efsa.2013.3429; Safety of L-valine for all animal species (EFSA FEEDAP) — 2008 — https://doi.org/10.2903/j.efsa.2008.872; Amino acids from chemical group 34. Flavouring Group Evaluation 26, Revision 1. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (EFSA AFC) — 2008 — https://doi.org/10.2903/j.efsa.2008.790; Scientific Opinion on the safety and efficacy of L-valine (L-valine, feed grade) produced by Escherichia coli NITE BP-01755 for all animal species based on a dossier submitted by Ajinomoto Eurolysine S.A.S (EFSA FEEDAP) — 2015 — https://doi.org/10.2903/j.efsa.2015.4110; Scientific Opinion on the safety and efficacy of L-valine (ValAMINO) produced by Corynebacterium glutamicum (DSM 25202) for all animal species, based on a dossier submitted by Evonik Industries AG (EFSA FEEDAP) — 2014 — https://doi.org/10.2903/j.efsa.2014.3795.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/38864
- EFSA OpenFoodTox (updated 2026-10-04): https://doi.org/10.5281/zenodo.8120114
- EPA Chemical and Products Database (updated March 2000): http://siri.org/msds/f2/cjt/cjttp.html
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA Inactive Ingredient Database (updated 2026-01-09): https://www.fda.gov/drugs/drug-approvals-and-databases/inactive-ingredients-database-download
- FDA National Drug Code Directory (updated 2027-12-31): https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory-support-files
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:HG18B9YRS7
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/6287

_Assessed by Greenveil._