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Sodium pidolate

CAS 2494-03-3 · 0/100 · High conf.

Also registered as 3 other CAS numbers

52497-17-3 · 53935-45-8 · 28874-51-3

Sodium pidolate chemical structure

Concern score

0/100Low concern — well-established and permitted without restriction (CIR safe as used; EU CosIng).
High confidence

Sodium pidolate in plain language

What it is

On cosmetic ingredient lists it appears as “Sodium PCA”.

Also known as Sodium PCA · 2-PYRROLIDONE-5-CARBOXYLIC acid sodium salt · L-sodium pidolate · Proline, 5-OXO-, monosodium salt, l- · Sodium l-pyroglutamate · Sodium pyroglutamate

Show all 23 names

Sodium (2S)-5-oxopyrrolidine-2-carboxylate · 2-Pyrrolidinone-5-carboxylic acid sodium salt · 5-Carboxy-2-pyrrolidone sodium salt · 5-Oxo-L-proline monosodium salt · 5-oxo-L-prolinate de sodium · 5-oxo-L-prolinato de sodio · Ajidew N 50 · Ajidew NL 50 · Ec 249-277-1 · L-5-Oxoproline monosodium salt · L-Proline, 5-oxo-, monosodium salt · Pdsi 101 · Pidolate Sodium · Sodium 5-oxo-2-pyrrolidinecarboxylate · Sodium L-pyrrolidonecarboxylate · Sodium pyrrolidone-5-carboxylate · UNII-1V74VH163T

What it does

Used in cosmetics as a humectant, a skin-conditioning agent and a hair conditioner.

  • Humectant
  • Skin conditioning
  • Hair conditioning
  • Antistatic
  • Conditioner
Is it a concern?
Low concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 2261 composition records across product categories including Personal care, Medical/dental, Construction.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Sodium pidolate appears in these published regulatory listings.

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Industrial
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 2261 composition records across product categories including Personal care, Medical/dental, Construction. EPA CPDat classifies this chemical for functional uses including Humectant, Anti-static agent, Softener and conditioner.
    • EPA CPDat observed this chemical in 2261 composition records across product categories including Personal care, Medical/dental, Construction. EPA CPDat classifies this chemical for functional uses including Humectant, Anti-static agent, Softener and conditioner.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Sodium pidolate. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Sodium pidolate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

6 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →
  • EPA Chemical and Products Database

    exposure · updated september 28, 2015

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Sodium pidolate in a product composition. These are source records, not Greenveil catalog products.

Source records

2,261

Named organisations

6

Personal careMedical/dentalConstructionBatteries

Typical roles

HumectantSkin conditioningHair conditioningAntistaticConditioner
See products using Sodium pidolate →

Catalog

Found in these products

Their ingredient lists include Sodium pidolate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Sodium pidolate in the catalog.