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  • pharma

Silymarin

CAS 65666-07-1

Concern score

Not assessed — no hazard data yet.

Silymarin in plain language

What it is

Also known as Milk thistle · Silybum marianum seed · Milk thistle silymarin · Milkthistle fruit (silybum marianum l. gaertner) · Silybi fructus · Silybi mariani fructus (silybum marianum l. gaertner)

Show all 31 names

Silybum marianum dry fruit · Silybum marianum fruit · Silybum marianum extract · Silybum marianum fruit extract · Silybum marianum seed extract · Cardui mariae fructus · Fruit of silybum marianum · Holy thistle seed · Lady's thistle seed · Mariana mariana seed · Mary's thistle seed · Milk thistle fruit · Milk thistle seed · Shuifeiji · Apihepar · Flavobion · Karsilin · Laragon · Legalon · Pluropon · Silarin · Silybum marianum · Silystrong · Carduus marianus · Carduus marianus seed

What it does

We don't have a plain-language description for Silymarin yet.

Is it a concern?
We haven't assessed a concern score for this ingredient yet.

Regulation

No restrictions found. Silymarin appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 140 active drug products and 155 total products.
    • FDA NDC lists this ingredient in 140 active drug products and 155 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as structurallydiverse.
    • openFDA substance registry classifies this ingredient as structurallydiverse.Source →

Evidence & sources

No graded research studies for Silymarin yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

4 data sources

Where this comes from

  • EPA Chemical and Products Database

    exposure · updated 2020-08-31

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2029-12-19

    Open →
  • openFDA Substance

    registry · updated 2026-05-24

    Open →
Reference links (2)
Openfda substance

en.wikipedia.org

Allergen profile

Canonical allergen markers detected on this ingredient. Each row is derived from the ingredient’s name or synonyms matching a known allergen class — useful when scanning a label for a specific allergy context.

  • DairyContains · Oral (ingested)

    Source: chemindex_name_match

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often FDA National Drug Code directory has listed Silymarin in a product composition. These are source records, not Greenveil catalog products.

Source records

155

See products using Silymarin →

Catalog

Found in these products

Their ingredient lists include Silymarin; each product's own rating depends on its whole formula, so it is shown on the product page, not here.