beauty
cleaning
food
industrial

1,2-Benzisothiazolin-3-one

CAS 1329616-16-1 · 20/100 · High conf.

Also registered as 17 other CAS numbers

40991-37-5 · 54392-14-2 · 73904-70-8 · 75037-67-1 · 101964-01-6 · 552320-00-0 · 919284-21-2 · 934197-15-6 · 1094749-54-8 · 1148150-72-4 · 1376937-61-9 · 1399460-92-4 · 1623463-70-6 · 1813531-93-9 · 1982328-85-7 · 2376801-76-0 · 2634-33-5

1,2-Benzisothiazolin-3-one chemical structure

Concern score

20/100Minor concern based on regulatory listings.

High confidence

1,2-Benzisothiazolin-3-one in plain language

What it is: On cosmetic ingredient lists it appears as “Benzisothiazolinone”.
Also known as Benzisothiazolinone · 1,2-Benzisothiazol-3(2H)-one · 1,2-Benzothiazol-3(2H)-one · 1,2-benzothiazol-3-one · 1,2-BENZISOTHIAZOLINE-3-ONE · 1,2-BENZOISOTHIAZOLIN-3-ONE
Show all 24 names
1,2-Benzisothiazol-3(2H)-on · 1,2-Benzisothiazol-3-one · 1,2-Benzisothiazolone · 1,2-Benzisothizolin-3-one · 1,2-Benzoisothiazol-3-one · 1,2-bencisotiazol-3(2H)-ona · 1,2-benzisothiazole-3(2H)-one · 2,3-dihydro-1,2-benzothiazol-3-one · 3-HYDROXY-1,2-BENZISOTHIAZOLE · BENZISOTHIAZOL-3(2H)-ONE, 1,2- · BENZISOTHIAZOLIN-3-ONE · BENZOISOTHIAZOL-3-ONE · Oristar bit · Proxel · Proxel PL · benzisothiazolone · biocide · substituted thiazolin-3-one
What it does: Used in cosmetics as an antimicrobial.
Antimicrobial
Antioxidant
Preservative
Fragrance
Is it a concern?: Minor concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 844 composition records across product categories including Construction and building materials, Raw materials, Home maintenance.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. 1,2-Benzisothiazolin-3-one appears in these published regulatory listings.

Recorded in these product areas

Found in consumer products
Cleaning
Industrial

EUEFSAEFSA opinion2 entries
- Scientific Opinion of the Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request related to a 16th list of substances for food contact materials (EFSA AFC)Source →
- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the presence of 1,2-Benzisothiazolin-3-one as an impurity in saccharin used as a food additive (EFSA AFC)Source →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 844 composition records across product categories including Construction and building materials, Raw materials, Home maintenance. EPA CPDat classifies this chemical for functional uses including Preservative, Antioxidant, Biocide.
- EPA CPDat observed this chemical in 844 composition records across product categories including Construction and building materials, Raw materials, Home maintenance. EPA CPDat classifies this chemical for functional uses including Preservative, Antioxidant, Biocide.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
EFSA
European Food Safety Authority
- Scientific Opinion of the Panel on food additives, flavourings, processing aids and materials in contact with food (AFC) on a request related to a 16th list of substances for food contact materials (EFSA AFC)
  2007 · EU EFSA listing · Read the source →
- Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in Contact with Food on the presence of 1,2-Benzisothiazolin-3-one as an impurity in saccharin used as a food additive (EFSA AFC)
  2007 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for 1,2-Benzisothiazolin-3-one yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EFSA OpenFoodTox
regulatory · updated 2026-10-04
Open →
EPA Chemical and Products Database
exposure · updated october 6, 2016
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often EPA CPDat has listed 1,2-Benzisothiazolin-3-one in a product composition. These are source records, not Greenveil catalog products.

Source records

844

Named organisations

Construction and building materialsRaw materialsHome maintenanceSpecialty occupational productsElectronics/small appliancesLaboratory supplies

Typical roles

AntimicrobialAntioxidantPreservativeFragrance

See products using 1,2-Benzisothiazolin-3-one →

Catalog

Found in these products

Their ingredient lists include 1,2-Benzisothiazolin-3-one; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 122 →Find products without it →