beauty
cleaning
industrial
pharma

Hydroxyethylpiperazine ethane sulfonic acid

CAS 7365-45-9

Concern score

Not assessed — no hazard data yet.

Hydroxyethylpiperazine ethane sulfonic acid in plain language

What it is: Also known as Hepes · (4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid · 1-PIPERAZINEETHANESULFONIC acid, 4-(2-HYDROXYETHYL)- · N-2-HYDROXYETHYLPIPERAZINE N'-2'-ETHANESULPHONIC acid · 4-(2-HYDROXYETHYL)-1-PIPERAZINEETHANE sulfonic acid · 4-(2-Hydroxyethyl)-1-piperazineethanesulfonic acid
Show all 12 names
4-(2-Hydroxyethyl)piperazin-1-ylethansulfonsaure · 4-(2-hydroxyethyl)piperazin-1-ylethanesulphonic acid · 4-(2-hydroxyethyl)piperazine-1-ethane-sulfonic acid · AKOS025243245 · HB5186 · hepes (buffer)
What it does: Used in cosmetics as a pH buffer.
Buffering
pH adjuster
Is it a concern?: We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Hydroxyethylpiperazine ethane sulfonic acid appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Beauty
Cleaning
Industrial

USFDAinactive ingredient database2 entries
- Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 41 mgSource →
- Route: INTRAVENOUS; Dosage form: LIQUID; Potency: 0.6 %w/vSource →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 94 composition records across product categories including Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including pH regulating agent.
- EPA CPDat observed this chemical in 94 composition records across product categories including Laboratory supplies, Personal care. EPA CPDat classifies this chemical for functional uses including pH regulating agent.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
- FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Hydroxyethylpiperazine ethane sulfonic acid. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.

Evidence & sources

No graded research studies for Hydroxyethylpiperazine ethane sulfonic acid yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

8 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated September 2018
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

chemicalbook.com

Read →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Hydroxyethylpiperazine ethane sulfonic acid in a product composition. These are source records, not Greenveil catalog products.

Source records

Named organisations

Laboratory suppliesPersonal care

Typical roles

BufferingpH adjuster

See products using Hydroxyethylpiperazine ethane sulfonic acid →

Catalog

Found in these products

Their ingredient lists include Hydroxyethylpiperazine ethane sulfonic acid; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 58 →Find products without it →