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Ectoine

CAS 134522-10-4

Also registered as 2 other CAS numbers

162763-51-1 · 96702-03-3

Ectoine chemical structure

Concern score

Not assessed — no hazard data yet.

Ectoine in plain language

What it is

On cosmetic ingredient lists it appears as “Ectoin”.

Also known as Ectoin · (4S)-2-Methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid · (6S)-2-methyl-1,4,5,6-tetrahydropyrimidine-6-carboxylic acid · (4S)-2-Methyl-1,4,5,6-tetrahydro-4-pyrimidinecarboxylic acid · (4S)-2-Methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid · (4S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylate

Show all 12 names

(4S)-3,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid · (S)-2-Methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid · (S)-2-methyl-1,4,5,6-tetrahydropyrimidine-4-carboxylic acid · 1,4,5,6-Tetrahydro-2-methyl-4-pyrimidinecarboxylic acid · 2-methyl-3,4,5,6-tetrahydropyrimidine-4-carboxylic acid · L-Ectoine

What it does

Used in cosmetics as a skin-conditioning agent.

  • Skin conditioning
  • pH adjuster
  • Conditioner
Is it a concern?
We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.

Regulation

No restrictions found. Ectoine appears in these published regulatory listings.

  • In marketed US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 52 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, pH regulating agent.
    • EPA CPDat observed this chemical in 52 composition records across product categories including Personal care. EPA CPDat classifies this chemical for functional uses including Softener and conditioner, pH regulating agent.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 1 active drug products and 1 total products.
    • FDA NDC lists this ingredient in 1 active drug products and 1 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

No expert opinion on file for Ectoine. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Ectoine yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

7 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often EPA CPDat has listed Ectoine in a product composition. These are source records, not Greenveil catalog products.

Source records

52

Named organisations

6

Personal care

Typical roles

Skin conditioningpH adjusterConditioner
See products using Ectoine →

Catalog

Found in these products

Their ingredient lists include Ectoine; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 29 →Find products without it →