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Tribasic calcium phosphate

CAS 12167-74-7

Also registered as 10 other CAS numbers

1337-78-6 · 29796-40-5 · 205873-50-3 · 221359-86-0 · 947383-76-8 · 1398505-50-4 · 2172828-58-7 · 2376822-12-5 · 2608052-30-6 · 2639476-81-4

Concern score

Not assessed — no hazard data yet.

Tribasic calcium phosphate in plain language

What it is

Also known as Durapatite · Calcium hydroxide phosphate (Ca5(OH)​(PO4)​3) · Calcium hydroxide phosphate (5/1/3) · Calcium hydroxide phosphate · Calcium hydroxide phosphate (Ca10(OH)2(PO4)6) · Calcium hydroxide phosphate (Ca5(OH)(PO4)3)

Show all 10 names

Hydroxylapatite · Pentacalcium hydroxide tris(orthophosphate) · calcium phosphate tribasic/tricalcium phosphate · hydroxyapatite

What it does

Used in consumer products as a colourant, an emulsifier and an abrasive.

  • Colourant
  • Emulsifier
  • Abrasive
  • Oral care
Is it a concern?
We haven't assessed a concern score for this ingredient yet.

Regulation

No restrictions found. Tribasic calcium phosphate appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Beauty
  • Cleaning
  • Industrial
  • USFDAinactive ingredient database10 entries — 3 administration routes
    • Route: BUCCAL; Dosage form: TABLET; Potency: 99.2 mgSource →
    • Route: ORAL; Dosage form: CAPSULE; Maximum daily exposure: 176 mgSource →
    • Route: ORAL; Dosage form: CAPSULE, EXTENDED RELEASE; Potency: 32.73 mgSource →
    • Route: ORAL; Dosage form: TABLET; Maximum daily exposure: 330 mgSource →
    • Route: ORAL; Dosage form: TABLET, CHEWABLE; Potency: 130 mgSource →
    • Route: ORAL; Dosage form: TABLET, COATED; Potency: 40 mgSource →
    • Route: ORAL; Dosage form: TABLET, DELAYED RELEASE; Potency: 333.3 mgSource →
    • Route: ORAL; Dosage form: TABLET, EXTENDED RELEASE; Maximum daily exposure: 750 mgSource →
    • Route: ORAL; Dosage form: TABLET, FILM COATED; Potency: 21.8 mgSource →
    • Route: SUBLINGUAL; Dosage form: TABLET; Potency: 99.2 mgSource →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 40 composition records across product categories including Laboratory supplies, Cleaning and safety, Personal care. EPA CPDat classifies this chemical for functional uses including Filler, Abrasive, Oral Care Agent.
    • EPA CPDat observed this chemical in 40 composition records across product categories including Laboratory supplies, Cleaning and safety, Personal care. EPA CPDat classifies this chemical for functional uses including Filler, Abrasive, Oral Care Agent.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 236 active drug products and 264 total products.
    • FDA NDC lists this ingredient in 236 active drug products and 264 total products.Source →

Expert safety opinions

No expert opinion on file for Tribasic calcium phosphate. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

Evidence & sources

No graded research studies for Tribasic calcium phosphate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

4 data sources

Where this comes from

  • EPA Chemical and Products Database

    exposure · updated September 2018

    Open →
  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →
  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →
  • FDA National Drug Code Directory

    regulatory · updated 2030-07-21

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Fragrance avoidance

Nothing to weigh for this context yet.

No signal in this context

We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.

Where it has been recorded

How often FDA National Drug Code directory has listed Tribasic calcium phosphate in a product composition. These are source records, not Greenveil catalog products.

Source records

264

Typical roles

ColourantEmulsifierAbrasiveOral care
See products using Tribasic calcium phosphate →

Catalog

Found in these products

Their ingredient lists include Tribasic calcium phosphate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Tribasic calcium phosphate in the catalog.