# EDETIC ACID

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid6022977
Categories: beauty, cleaning, food, industrial, pharma
Functions: Chelating, Antioxidant synergist, preservative, sequestrant, synergist, Surfactant, Chelating agent, pH adjuster, Flavouring
Identifier: DTXSID6022977

> EDETIC ACID: Used in cosmetics as a chelating agent. Greenveil chemical-concern score: 40/100 — Moderate concern based on regulatory listings.. Compiled from 9 published data sources.

## Safety assessment

- Chemical concern score: 40/100 — Moderate concern based on regulatory listings.
- Confidence in this assessment: High
- Is it a concern? Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 1909 composition records across product categories including Furniture and furnishings, Food and drug, Laboratory supplies.

## Regulatory status

- EU: Active — Listed in CosIng inventory for cosmetic use.
- GLOBAL: Evaluated — JECFA evaluation record.
- GLOBAL: 0-2.5 mg/kg bw — JECFA evaluation lists ADI 0-2.5 mg/kg bw. Functional class: antioxidant synergist, preservative, sequestrant, synergist.
- US: commercial use observed — EPA CPDat observed this chemical in 1909 composition records across product categories including Furniture and furnishings, Food and drug, Laboratory supplies. EPA CPDat classifies this chemical for functional uses including Chelating agent, Binder, Flavouring and nutrient.
- US: inactive ingredient database — Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 2 mg
- US: inactive ingredient database — Route: ORAL; Dosage form: TABLET; Potency: 4 mg
- US: inactive ingredient database — Route: ORAL; Dosage form: TABLET, FILM COATED; Potency: 0.2 mg
- US: inactive ingredient database — Route: RECTAL; Dosage form: SUPPOSITORY; Maximum daily exposure: 7 mg
- US: inactive ingredient database — Route: SUBCUTANEOUS; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 2 mg
- US: inactive ingredient database — Route: SUBMUCOSAL; Dosage form: INJECTION, SOLUTION; Potency: 0.03 %w/v
- US: inactive ingredient database — Route: TOPICAL; Dosage form: CREAM; Potency: 0.5 %w/w
- US: inactive ingredient database — Route: TOPICAL; Dosage form: GEL; Potency: 0.1 %w/w
- US: inactive ingredient database — Route: TOPICAL; Dosage form: SHAMPOO; Potency: 0.2 %w/w
- US: inactive ingredient database — Route: TOPICAL; Dosage form: SOLUTION; Potency: 0.5 %w/w
- US: inactive ingredient database — Route: TOPICAL; Dosage form: SUSPENSION; Potency: 0.06 %w/v
- US: marketed drug occurrence — FDA NDC lists this ingredient in 2 drug products and 2 package presentations.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as chemical.
- US: inactive ingredient database — Route: INTRAMUSCULAR; Dosage form: INJECTION, SOLUTION; Maximum daily exposure: 2 mg
- US: inactive ingredient database — Route: AURICULAR (OTIC); Dosage form: SUSPENSION; Potency: NA

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.
- JECFA (Joint FAO/WHO Expert Committee on Food Additives): JECFA evaluation record. — https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/219; JECFA evaluation lists ADI 0-2.5 mg/kg bw. Functional class: antioxidant synergist, preservative, sequestrant, synergist. — https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/386.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/33756
- EPA Chemical and Products Database (updated september 5, 2012): https://living-future.org/declare-products/polyester-polyester-compound-fabrics/
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA Inactive Ingredient Database (updated 2026-01-09): https://www.fda.gov/drugs/drug-approvals-and-databases/inactive-ingredients-database-download
- FDA National Drug Code Directory (updated 2027-09-02): https://www.fda.gov/drugs/drug-approvals-and-databases/national-drug-code-directory-support-files
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- WHO JECFA Database (updated 2026-10-04): https://apps.who.int/food-additives-contaminants-jecfa-database/Home/Chemical/219
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:9G34HU7RV0
- PubChem Live Enrichment (updated 2026-05-17): https://pubchem.ncbi.nlm.nih.gov/compound/6049

_Assessed by Greenveil._