- food
- pharma
Cholic acid
CAS 81-25-4
Also registered as 11 other CAS numbers
129874-08-4 · 116-68-7 · 10321-98-9 · 134353-30-3 · 728917-96-2 · 732303-80-9 · 882740-42-3 · 889875-66-5 · 904791-60-2 · 2222145-69-7 · 2599839-19-5
Concern score
Not assessed — no hazard data yet.
Cholic acid in plain language
Also known as 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholan-24-oic acid · Cholalic acid · 3,7,12-TRIHYDROXYCHOLANIC acid · 3-alpha,7-alpha,12-alpha-Trihydroxycholansaeure · 3alpha,7alpha,12alpha-Trihydroxy-5beta-cholanic acid · 3α,7α,12α-Trihydroxy-5β-cholan-24-oic acid
Show all 18 names
3α,7α,12α-Trihydroxy-5β-cholanic acid · 3α,7α,12α-Trihydroxy-5β-cholanoic acid · 3α,7α,12α-Trihydroxycholanic acid · Cholbam · Cholalin · Cholan-24-oic acid, 3,7,12-trihydroxy-, (3α,5β,7α,12α)- · Cholic acid, 5beta- · Cholsaeure · Colalin · Kolbam · Orphacol · cholicacid
Used in consumer products as a pH adjuster.
- pH adjuster
- We haven't assessed a concern score for this ingredient yet.
Regulation
No restrictions found. Cholic acid appears in these published regulatory listings.
- In marketed US drugs
- Found in consumer products
- Pharma
- Food
USEPAcommercial use observedEPA CPDat observed this chemical in 3 composition records across product categories including Food and drug. EPA CPDat classifies this chemical for functional uses including pH regulating agent.
- EPA CPDat observed this chemical in 3 composition records across product categories including Food and drug. EPA CPDat classifies this chemical for functional uses including pH regulating agent.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
- FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →
Expert safety opinions
No expert opinion on file for Cholic acid. These are the independent scientific bodies that assess ingredients like this one; we show an opinion only when a record we hold cites it.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
No JECFA evaluation on file.
EFSA
European Food Safety Authority
No EFSA opinion on file.
Evidence & sources
No graded research studies for Cholic acid yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.
Where this comes from
- Open →
EPA Chemical and Products Database
exposure · updated February 8, 2019
- Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
- Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
- Open →
FDA GSRS UNII
registry · updated 2026-02-26
- Open →
openFDA Substance
registry · updated 2026-05-24
- Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Suitability
Context-specific fit derived from published classifications and the current ingredient evidence profile.
Food use
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Fragrance avoidance
Nothing to weigh for this context yet.
We have no published hazard signal for this ingredient, so we cannot say how it behaves in this context — that is missing evidence, not a clean result.
Where it has been recorded
How often EPA CPDat has listed Cholic acid in a product composition. These are source records, not Greenveil catalog products.
Source records
3
Named organisations
3
Food and drug
Typical roles
pH adjuster