beauty
cleaning
food
industrial

Sodium thiosulfate

CAS 1374442-74-6 · 40/100 · High conf.

Also registered as 2 other CAS numbers

7772-98-7 · 10102-17-7

Concern score

40/100Moderate concern based on regulatory listings.

High confidence

Sodium thiosulfate in plain language

What it is: Also known as Sodium thiosulfate pentahydrate · Sodium thiosulfate hydrate · pentahydrate Sodium thiosulfate · Sodium sulfurothioate--water (2/1/5) · Thiosulfuric acid, disodium salt, pentahydrate · Antichlor
Show all 26 names
DB-020 · Detoxol (TN) · Disodium thiosulfate pentahydrate · Disodium thiosulphate pentahydrate · Natriumthiosulfat-pentahydrat · Na2S2O3.5H2O · Pedmarqsi (TN) · Sodium thiosulphate pentahydrate · Sodium thiosulfate (Na2S2O3) pentahydrate · Sodium thiosulphate · Sulfactol (TN) · Thiosulfate, sodium, pentahydrate · Thiosulfuric acid (H2S2O3), sodium salt, hydrate (1:2:5) · Thiosulfuric acid, (H2S2O3), disodium salt, pentahydrate · Tinver · UNII-HX1032V43M · pentahydrate of sodium thiosulfate · sodium thiosulfate (7772-98-7) · Nithiodote component sodium thiosulfate · natrii thiosulfas
What it does: Used in cosmetics as a reducing agent.
Reducing
Antioxidant, preservative, sequestrant
Is it a concern?: Moderate concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 119 composition records across product categories including Laboratory supplies, Specialty occupational products, Cleaning products and household care.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Sodium thiosulfate appears in these published regulatory listings.

In marketed US drugs
Inactive ingredient in US drugs

Recorded in these product areas

Found in consumer products
Cleaning
Pharma
Food
Industrial

USFDAinactive ingredient database10 entries — 4 administration routes
- Route: OPHTHALMIC; Dosage form: SOLUTION; Potency: 0.5 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SOLUTION/ DROPS; Potency: 0.31 %w/vSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION; Potency: 0.32 %w/wSource →
- Route: OPHTHALMIC; Dosage form: SUSPENSION/ DROPS; Potency: 3.15 %w/wSource →
- Route: ORAL; Dosage form: CAPSULE; Potency: 20 mgSource →
- Route: INTRAVENOUS; Dosage form: INJECTION; Maximum daily exposure: 18 mgSource →
- Route: ORAL; Dosage form: SOLUTION/ DROPS; Potency: 0.5 mg/1mlSource →
- Route: ORAL; Dosage form: TABLET; Potency: 3 mgSource →
- Route: TOPICAL; Dosage form: CREAM; Maximum daily exposure: 6 mgSource →
- Route: ORAL; Dosage form: SOLUTION; Potency: 22 mg/1mlSource →
EUCosIngActiveListed in CosIng inventory for cosmetic use.
- Listed in CosIng inventory for cosmetic use.Source →
GLOBALJECFA0-0.7 mg/kg bwJECFA evaluation lists ADI 0-0.7 mg/kg bw. Functional class: antioxidant, preservative, sequestrant.
- JECFA evaluation lists ADI 0-0.7 mg/kg bw. Functional class: antioxidant, preservative, sequestrant.Source →
USEPAcommercial use observedEPA CPDat observed this chemical in 119 composition records across product categories including Laboratory supplies, Specialty occupational products, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Processing aids not otherwise specified.
- EPA CPDat observed this chemical in 119 composition records across product categories including Laboratory supplies, Specialty occupational products, Cleaning products and household care. EPA CPDat classifies this chemical for functional uses including Processing aids not otherwise specified.Source →
USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 2 active drug products and 2 total products.
- FDA NDC lists this ingredient in 2 active drug products and 2 total products.Source →
USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
- openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

SCCS
EU Scientific Committee on Consumer Safety
No SCCS opinion on file.
CIR
Cosmetic Ingredient Review (US expert panel)
No CIR safety assessment on file.
JECFA
Joint FAO/WHO Expert Committee on Food Additives
- JECFA evaluation lists ADI 0-0.7 mg/kg bw. Functional class: antioxidant, preservative, sequestrant.
  Year not recorded · GLOBAL JECFA listing · Read the source →

Evidence & sources

No graded research studies for Sodium thiosulfate yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

CosIng
regulatory · updated 2026-09-23
Open →
EPA Chemical and Products Database
exposure · updated January 7, 2008
Open →
EPA DSSTox Identifiers
chemistry · updated 2025-12-29
Open →
FDA Inactive Ingredient Database
regulatory · updated 2026-01-09
Open →
FDA National Drug Code Directory
regulatory · updated 2027-12-31
Open →
FDA GSRS UNII
registry · updated 2026-02-26
Open →
WHO JECFA Database
regulatory · updated 2026-10-04
Open →
openFDA Substance
registry · updated 2026-05-24
Open →
PubChem Live Enrichment
chemistry · updated 2026-05-17
Open →

Reference links (1)

Openfda substance

adisinsight.springer.com

Read →

Allergen profile

Canonical allergen markers detected on this ingredient. Each row is derived from the ingredient’s name or synonyms matching a known allergen class — useful when scanning a label for a specific allergy context.

SulphitesContains · Oral (ingested)
Source: chemindex_name_match

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

No fragrance-linked caution surfaced in the current profile.

Good fit

This ingredient does not currently read as a fragrance-linked driver in the published evidence and hazard profile.

Where it has been recorded

How often EPA CPDat has listed Sodium thiosulfate in a product composition. These are source records, not Greenveil catalog products.

Source records

119

Named organisations

Laboratory suppliesSpecialty occupational productsCleaning products and household careFood and drugCleaning and safetyRaw materials

Typical roles

ReducingAntioxidant, preservative, sequestrant

See products using Sodium thiosulfate →

Catalog

Found in these products

Their ingredient lists include Sodium thiosulfate; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 18 →Find products without it →