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Serine

CAS 6898-95-9 · 60/100 · High conf.

Also registered as 3 other CAS numbers

154605-73-9 · 56-45-1 · 302-84-1

Serine chemical structure

Concern score

60/100High concern based on regulatory listings.
High confidence

Serine in plain language

What it is

Also known as L-serine · D,L-Serine · (2S)-2-AMINO-3-HYDROXY-PROPANOIC acid · (2S)-2-amino-3-hydroxypropanoic acid · L-(-)-serine · (S)-2-Amino-3-hydroxypropanoic acid

Show all 24 names

(S)-Serine · (S)-alpha-Amino-beta-hydroxypropionic acid · 2-Amino-3-hydroxypropanoic acid · 3-Hydroxyalanine · L-2-Amino-3-hydroxypropionic acid · L-3-Hydroxy-2-aminopropionic acid · L-3-Hydroxy-alanine · L-Serin · L-ser · L-serina · Propanoic acid, 2-amino-3-hydroxy-, (S)- · SER (IUPAC abbrev) · Serene · Serina · alpha-Amino-beta-hydroxypropionic acid · beta-Hydroxy-L-alanine · beta-Hydroxyalanine · serinum

What it does

Used in cosmetics as a skin-conditioning agent, a hair conditioner and an antistatic agent.

  • Skin conditioning
  • Hair conditioning
  • Antistatic
  • Fragrance
  • Flavouring
Is it a concern?
High concern: no hazard classifications on record. It is listed for cosmetic use in the EU.

Why it's flagged

EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.

The score describes this ingredient's chemical identity — its hazard profile from published classifications and regulatory status — not the safety of any product it appears in.

Regulation

No restrictions found. Serine appears in these published regulatory listings.

  • In marketed US drugs
  • Inactive ingredient in US drugs

Recorded in these product areas

  • Found in consumer products
  • Industrial
  • EUEFSAEFSA opinion3 entries
    • Amino acids from chemical group 34. Flavouring Group Evaluation 26, Revision 1. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (EFSA AFC)Source →
    • Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP)Source →
    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 26: Amino acids from chemical group 34(Commission Regulation (EC) No 1565/2000 of 18 July 2000) (EFSA AFC)Source →
  • USFDAinactive ingredient database2 entries
    • Route: INTRAVENOUS; Dosage form: INJECTION; Potency: 0.5 %w/vSource →
    • Route: INTRAVENOUS; Dosage form: INJECTION, SOLUTION; Potency: 0.18 %w/vSource →
  • EUCosIngActiveListed in CosIng inventory for cosmetic use.
    • Listed in CosIng inventory for cosmetic use.Source →
  • USEPAcommercial use observedEPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Flavouring and nutrient.
    • EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. EPA CPDat classifies this chemical for functional uses including Flavouring and nutrient.Source →
  • USFDAmarketed drug occurrenceFDA NDC lists this ingredient in 59 active drug products and 60 total products.
    • FDA NDC lists this ingredient in 59 active drug products and 60 total products.Source →
  • USFDAlisted in openFDA substanceopenFDA substance registry classifies this ingredient as chemical.
    • openFDA substance registry classifies this ingredient as chemical.Source →

Expert safety opinions

Independent scientific assessments cited by the records we hold, with the year and link where the record gives one.

  • SCCS

    EU Scientific Committee on Consumer Safety

    No SCCS opinion on file.

  • CIR

    Cosmetic Ingredient Review (US expert panel)

    No CIR safety assessment on file.

  • EFSA

    European Food Safety Authority

    • Amino acids from chemical group 34. Flavouring Group Evaluation 26, Revision 1. Scientific opinion of the Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) (EFSA AFC)

      2008 · EU EFSA listing · Read the source →

    • Scientific Opinion on the safety and efficacy of the use of amino acids (chemical group 34) when used as flavourings for all animal species (EFSA FEEDAP)

      2014 · EU EFSA listing · Read the source →

    • Opinion of the Scientific Panel on Food Additives, Flavourings, Processing Aids and Materials in contact with Food (AFC) on a request from the Commission related to Flavouring Group Evaluation 26: Amino acids from chemical group 34(Commission Regulation (EC) No 1565/2000 of 18 July 2000) (EFSA AFC)

      2010 · EU EFSA listing · Read the source →

Evidence & sources

No graded research studies for Serine yet. This record is compiled from the published data sources below — registries and regulatory listings, not study findings.

9 data sources

Where this comes from

  • CosIng

    regulatory · updated 2026-09-23

    Open →

  • EFSA OpenFoodTox

    regulatory · updated 2026-10-04

    Open →

  • EPA Chemical and Products Database

    exposure · updated February 8, 2019

    Open →

  • EPA DSSTox Identifiers

    chemistry · updated 2025-12-29

    Open →

  • FDA Inactive Ingredient Database

    regulatory · updated 2026-01-09

    Open →

  • FDA National Drug Code Directory

    regulatory · updated 2027-12-31

    Open →

  • FDA GSRS UNII

    registry · updated 2026-02-26

    Open →

  • openFDA Substance

    registry · updated 2026-05-24

    Open →

  • PubChem Live Enrichment

    chemistry · updated 2026-05-17

    Open →

Suitability

Context-specific fit derived from published classifications and the current ingredient evidence profile.

Food use

Food-use source coverage is present in the current record.

Good fit

The ingredient appears in food-oriented source coverage or allowed-use references, which makes food use easier to support than a context with no domain signal at all.

Fragrance avoidance

Not a strong fit for fragrance avoidance because it carries Fragrance.

Avoid

The ingredient itself is a fragrance-linked signal, so it is better treated as an avoid case when fragrance exposure is the main concern.

Where it has been recorded

How often FDA National Drug Code directory has listed Serine in a product composition. These are source records, not Greenveil catalog products.

Source records

60

Typical roles

Skin conditioningHair conditioningAntistaticFragranceFlavouring
See products using Serine →

Catalog

Found in these products

Their ingredient lists include Serine; each product's own rating depends on its whole formula, so it is shown on the product page, not here.

See all 219 →Find products without it →

Co-occurrence

Often appears with

Ingredients that frequently appear alongside Serine in the catalog.