# Hepatocyte growth factor

URL: https://app.greenveil.ai/ingredients/ingredient_dtxsid_dtxsid7040491
Categories: beauty, industrial
Functions: Antioxidant, Skin conditioning, Hair conditioning
Identifier: DTXSID7040491

> Hepatocyte growth factor: Used in cosmetics as an antioxidant, a skin-conditioning agent and a hair conditioner. EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products. Compiled from 5 published data sources.

## Safety assessment

- Chemical concern: not yet assessed
- Is it a concern? We haven't assessed a concern score for this ingredient yet. It is listed for cosmetic use in the EU.
- Rationale: EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.

## Regulatory status

- EU: Active — sh-Polypeptide-62 is a single chain synthetic human peptide, produced by fermentation in E.Coli. The starting gene is a synthesized copy of the human gene which codes for Hepatocyte Growth Factor used as such or adapted to the production host. It contains a maximum of 728 amino acids which may contain disulfide bonds and/or glycosylation. The protein consists of the proper sequence of the 20 standard amino acids.
- US: commercial use observed — EPA CPDat observed this chemical in 0 composition records across product categories including unclassified products.
- US: listed in openFDA substance — openFDA substance registry classifies this ingredient as protein.

## Expert safety opinions

- SCCS (EU Scientific Committee on Consumer Safety): no opinion on file.
- CIR (Cosmetic Ingredient Review (US expert panel)): no opinion on file.

## Data sources

- CosIng (updated 2026-09-23): https://ec.europa.eu/growth/tools-databases/cosing/details/91570
- EPA Chemical and Products Database (updated 2019-03-26): https://www.wada-ama.org/en/resources/world-anti-doping-program/prohibited-list
- EPA DSSTox Identifiers (updated 2025-12-29): https://epa.figshare.com/articles/dataset/Chemistry_Dashboard_Data_DSSTox_Identifiers_Mapped_to_CAS_Numbers_and_Names/5588566
- FDA GSRS UNII (updated 2026-02-26): https://precision.fda.gov/uniisearch/
- openFDA Substance (updated 2026-05-24): https://api.fda.gov/other/substance.json?search=unii:2TEN8A78E7

_Assessed by Greenveil._